KERATOCONJUNCTIVITIS SICCA--PREVALENCE AND RISK FACTORS

干燥性角结膜炎——患病率和危险因素

• 批准号: 6295571
• 负责人: OLIVER SCHEIN
• 金额: $ 1.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6295571
• 关键词: Sjogren's syndrome; aging; autoimmune disorder; disease /disorder proneness /risk; drug adverse effect; epidemiology; human old age (65+); human subject; keratoconjunctivitis sicca; oxidative stress; sex hormones; smoking; tear; vision disorders

Keratoconjunctivitis sicca (KCS), or "dry eye", is an acquired condition of the elderly, principally affecting women, characterized by a spectrum of symptoms and signs including foreign body sensation, debilitating photophobia, and in severe cases visual loss from ocular surface breakdown. It has been estimated that this condition may afflict more than 15% of those aged 55 and over, and in the United States, over $100 million are spent annually on topical ocular lubricants alone. Despite this presumed prevalence of disease and associated health care costs, there have been no population-based estimates of the prevalence of KCS in the United States nor controlled studies directed at elucidating potential risk factors for this condition. We propose to examine a representative sample of 2,300 community dwelling persons age 65 and over. KCS will be assessed by means of a questionnaire, objective tests of tear function (Schirmer's testing, Rose Bengal scoring, tear film osmolarity, conjunctival impression cytology), and evaluation for evidence of primary or secondary Sjogren's syndrome. On the basis of these and related tests, we will estimate age-specific prevalence of KCS by categories of severity and associated disease. Previous laboratory or uncontrolled clinical studies have suggested possible risk factors for KCS including immune status, sex hormone status/reproductive history, systemic "drying" medications, smoking, and measures of oxidative stress. We will test these and other secondary hypotheses with a combination of questionnaires and serologic assays using nested case control studies.

干燥性角膜结膜炎（KCS），或“干眼”，是一种获得性病症， 老年人，主要是妇女，其特点是一系列的 症状和体征，包括异物感、虚弱 近视恐惧症，严重者因眼表破裂而丧失视力。 据估计，这种情况可能会影响超过15%的 55岁及以上的人，在美国，超过1亿美元的人， 每年仅花费在局部眼部润滑剂上。 尽管这一假设 疾病的流行和相关的医疗保健费用，没有 美国KCS患病率基于人群的估计 也没有对照研究，旨在阐明潜在的风险因素 这个条件。 我们建议对2，300个社区住宅进行有代表性的抽样调查， 65岁及以上的人。 KCS将通过问卷进行评估， 泪液功能的客观测试（Schirmer测试，玫瑰红评分， 泪膜渗透压、结膜印迹细胞学），以及 原发性或继发性干燥综合征的证据。 根据这些 和相关的测试，我们将估计年龄特异性患病率KCS， 严重程度和相关疾病的类别。 先前的实验室或非对照临床研究表明， KCS的可能危险因素包括免疫状态、性激素 状态/生育史、全身性“干燥”药物、吸烟，以及 氧化应激的措施。 我们将测试这些和其他次要的 问卷调查和血清学检测相结合的假设， 巢式病例对照研究。