Gold nanorod diagnostic test and data management system for detection and control of bovine tuberculosis

用于检测和控制牛结核病的金纳米棒诊断测试和数据管理系统

• 批准号: 75323
• 金额: $ 38.19万
• 依托单位: CLARITY BIOSOLUTIONS LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=75323
• 关键词: Gold; nanorod; diagnostic; test; data

Tuberculosis (TB) is a bacterial infection that mainly affects the lungs, causing a general state of illness, coughing and eventually death. Bovine tuberculosis (bTB) is caused by a particular bacterium that affects cows but can be passed on to practically all mammals, including humans. The usual route of infection is through the inhalation of infected droplets which are expelled from the lungs by coughing. Because the course of the disease is slow, an undetected cow can spread the disease to many others in a herd before it begins to show any visible signs of illness. Unregulated movement of infected but undetected cows, along with contact with infected wild animals such as badgers, are the major ways that the disease is spread.Accurate detection, herd management and movement control are critical to achieving the eradication of the disease. The current test for bovine tuberculosis on farm herds is relatively subjective relying on individual veterinary practitioner interpretation. It is also not sensitive enough to detect all the cows that are infected therefore making eradication impossible.Bovine TB control measures cost over £500 million in the last 10 years. Without intervention, costs are expected to top £1 billion over the next decade if no new action is taken. A new, effective test is urgently needed. This proposal would bring together an international consortium to lead the fight against tuberculosis in cattle. The ambitious consortium has set out to do a project that will eliminate inaccurate test results frequently experienced by farming communities across the country but also worldwide. These "false positive" results lead to the unnecessary slaughter of healthy animals and infected animals being missed, bringing enormous economic and emotional cost to farmers, society and governments. This collaboration allies Aberystwyth's world-leading biomarker research with Lateral Flow Diagnostic specialists Clarity Biosolutions, life science businesses, Dynamic Extractions, software specialists Bond Digital Health and Sona Nanotech in Canada, specialists in gold nanrod LF technology, to build a team of academic and industry experts because no single company can achieve this goal alone. The project combines the latest cutting-edge science and technological developments with world-class research, state of the art facilities and expertise, to develop a new highly accurate, objective test to rapidly detect, manage, control and ultimately eradicate bTB.

结核病（TB）是一种细菌感染，主要影响肺部，导致一般疾病，咳嗽，最终死亡。牛结核病（bTB）是由一种特殊的细菌引起的，这种细菌会影响奶牛，但几乎可以传染给所有哺乳动物，包括人类。通常的感染途径是通过吸入受感染的飞沫，这些飞沫通过咳嗽从肺部排出。由于疾病的过程是缓慢的，一个未被发现的奶牛可以在它开始显示任何明显的疾病迹象之前将疾病传播给牛群中的许多其他奶牛。受感染但未被检测到的奶牛的不受管制的移动，沿着与獾等受感染的野生动物的接触，是该疾病传播的主要途径。准确的检测、牛群管理和移动控制对于根除该疾病至关重要。目前对农场牛群进行的牛结核病检测相对主观，依赖于个体兽医的解释。它也不够敏感，无法检测出所有感染的奶牛，因此无法根除。在过去10年中，牛结核病控制措施花费了5亿多英镑。如果不采取新的行动，预计未来十年的成本将超过10亿英镑。迫切需要一种新的、有效的测试方法。这项提议将汇集一个国际财团，领导防治牛结核病的斗争。这个雄心勃勃的联盟已经着手进行一个项目，该项目将消除全国各地以及世界各地的农业社区经常遇到的不准确的测试结果。这些“假阳性”结果导致健康动物的不必要宰杀和被感染动物的错过，给农民、社会和政府带来巨大的经济和情感成本。这项合作联盟阿伯里斯特威斯的世界领先的生物标志物研究与侧向流诊断专家Clarity Biosolutions，生命科学业务，动态提取，软件专家邦德数字健康和索纳纳米技术在加拿大，专家在金纳米棒LF技术，建立一个团队的学术和行业专家，因为没有一家公司可以单独实现这一目标。该项目将最新的尖端科学技术发展与世界一流的研究、最先进的设施和专业知识相结合，开发出一种新的高度准确、客观的检测方法，以快速检测、管理、控制并最终根除bTB。