DRUG DEVELOPMENT AND CONSERVATION OF BIODIVERSITY IN WES

WES 的药物开发和生物多样性保护

• 批准号: 2866914
• 负责人: BRIAN G SCHUSTER
• 金额: $ 46.8万
• 依托单位: WALTER REED ARMY INSTITUTE OF RESEARCH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2866914
• 关键词: Africa; cooperative study; drug screening /evaluation; medicinal plants; plant ecology; plant extracts

West-central Africa contains the largest moist equatorial forest on the continent, indeed the second largest continuous tropical rain-forest in the world (3 million square km). The species richness of this region and its importance as a center for plant endemism makes it a key global center for biodiversity conservation. It is a unique area with great potential as a source of new molecular leads for drug development. The forest is currently facing major threats, including increased pressure from a growing human population and the destructive practices of logging and other commercial industry. This ICBG proposes to demonstrate that sustainable drug development is a viable alternative to such destructive activities as a source of income for local communities. This plan will encourage communities to protect their own resources. Our research design emphasizes the development of drugs for tropical diseases such as malaria and leishmaniasis as well as high-quality, affordable herbal medicines. We are also searching for new anti-HIV, anti-cancer and CNS drugs, as well as crop protection agents. The ICBG strategy is to use data from field ethnobotanical and ethnomedical surveys, plus biochemical information from the literature, to develop a prioritized list of plants for investigation. Such focus has been shown in our earlier work to markedly enhance the probability of discovering active lead compounds. We have established a 50-ha biodiversity plot in Cameroon as well as a network of 1-ha plots throughout Cameroon and Nigeria in unique vegetative zones in order to obtain long-term biological inventory and ecological dynamics data. A 50-ha plot in Nigeria is proposed in the present funding cycle. A database will link biochemical, ethnobotanical, economic and ecological data to allow the ICBG to determine the sustainability of long- term harvest of potentially valuable plants. Training, capacity building and infrastructure enhancement will be provided in all aspects of the project. The networks developed during the initial funding cycle will ensure that this project becomes a sustainable program which can operate and grow independently of this Group.

中西部非洲包含最大的赤道赤道森林 大陆，的确是第二大连续热带雨林 世界（300万平方公里）。该地区的物种丰富性 它作为植物民主中心的重要性使其成为全球关键的中心 用于生物多样性保护。这是一个具有巨大潜力的独特区域 用于药物开发的新分子铅的来源。森林是 目前面临重大威胁，包括增加的压力 人口不断增长以及伐木的破坏性实践和 其他商业工业。 该洲际弹道导弹建议证明可持续药物开发是 作为收入来源的这种破坏性活动的可行替代方案 对于当地社区。该计划将鼓励社区保护 他们自己的资源。我们的研究设计强调了 疟疾和利什曼病等热带疾病的药物以及 高质量，负担得起的草药。我们还在寻找新的 抗HIV，抗癌和CNS药物以及作物保护剂。 ICBG策略是使用现场民族植物学和 民族医学调查，以及文献中的生化信息 制定优先研究的植物清单以进行调查。这样的重点是 在我们较早的工作中显示了明显提高的可能性 发现活跃的铅化合物。 我们已经在喀麦隆建立了一个50 ha的生物多样性情节以及一个 整个喀麦隆和尼日利亚的1-HA地块网络在独特的营养中 为了获得长期生物库存和生态学的区域 动态数据。目前的资金提出了50 ha的地块 循环。数据库将链接生化，民族植物学，经济和 生态数据允许洲际弹道导弹确定长期的可持续性 术语收获潜在有价值的植物。培训，能力建设 并将在各个方面提供基础设施的增强 项目。在初始资金周期中开发的网络将 确保该项目成为可以运作的可持续计划 并独立于这个群体。