DRUG DEVELOPMENT AND CONSERVATION OF BIODIVERSITY IN WES

WES 的药物开发和生物多样性保护

• 批准号: 6078344
• 负责人: BRIAN G SCHUSTER
• 金额: $ 55万
• 依托单位: WALTER REED ARMY INSTITUTE OF RESEARCH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6078344
• 关键词: Africa; cooperative study; drug screening /evaluation; medicinal plants; plant ecology; plant extracts

West-central Africa contains the largest moist equatorial forest on the continent, indeed the second largest continuous tropical rain-forest in the world (3 million square km). The species richness of this region and its importance as a center for plant endemism makes it a key global center for biodiversity conservation. It is a unique area with great potential as a source of new molecular leads for drug development. The forest is currently facing major threats, including increased pressure from a growing human population and the destructive practices of logging and other commercial industry. This ICBG proposes to demonstrate that sustainable drug development is a viable alternative to such destructive activities as a source of income for local communities. This plan will encourage communities to protect their own resources. Our research design emphasizes the development of drugs for tropical diseases such as malaria and leishmaniasis as well as high-quality, affordable herbal medicines. We are also searching for new anti-HIV, anti-cancer and CNS drugs, as well as crop protection agents. The ICBG strategy is to use data from field ethnobotanical and ethnomedical surveys, plus biochemical information from the literature, to develop a prioritized list of plants for investigation. Such focus has been shown in our earlier work to markedly enhance the probability of discovering active lead compounds. We have established a 50-ha biodiversity plot in Cameroon as well as a network of 1-ha plots throughout Cameroon and Nigeria in unique vegetative zones in order to obtain long-term biological inventory and ecological dynamics data. A 50-ha plot in Nigeria is proposed in the present funding cycle. A database will link biochemical, ethnobotanical, economic and ecological data to allow the ICBG to determine the sustainability of long- term harvest of potentially valuable plants. Training, capacity building and infrastructure enhancement will be provided in all aspects of the project. The networks developed during the initial funding cycle will ensure that this project becomes a sustainable program which can operate and grow independently of this Group.

非洲中西部拥有非洲大陆上最大的湿润赤道森林 大陆，确实是第二大连续的热带雨林 世界（300万平方公里）。该地区的物种丰富度和 它作为植物特有中心的重要性使其成为重要的全球中心 用于生物多样性保护。这是一个独特的地区，潜力巨大 药物开发新分子先导物的来源。森林是 目前面临重大威胁，包括来自 不断增长的人口和破坏性的伐木行为 其他商业行业。 该 ICBG 旨在证明可持续药物开发是一个 此类破坏性活动的可行替代方案作为收入来源 为当地社区。该计划将鼓励社区保护 自己的资源。我们的研究设计强调发展 治疗疟疾和利什曼病等热带疾病的药物 高品质、价格实惠的草药。我们也在寻找新的 抗艾滋病毒、抗癌和中枢神经系统药物，以及作物保护剂。 ICBG 的策略是使用来自野外民族植物学和 民族医学调查，加上文献中的生化信息， 制定一份优先调查植物清单。这样的专注有 我们早期的工作表明，显着提高了 发现活性先导化合物。 我们在喀麦隆建立了一个 50 公顷的生物多样性地块以及一个 遍布喀麦隆和尼日利亚的 1 公顷土地网络，拥有独特的植被 区以获得长期的生物库存和生态 动态数据。目前的资金提议在尼日利亚建设一块 50 公顷的土地 循环。一个数据库将生物化学、民族植物学、经济和 生态数据使 ICBG 能够确定长期生态系统的可持续性 潜在有价值的植物的定期收获。培训、能力建设 并将在各个方面加强基础设施建设 项目。在初始融资周期内开发的网络将 确保该项目成为一个可以运行的可持续计划 并独立于本集团而发展。