DRUG DEVELOPMENT AND CONSERVATION OF BIODIVERSITY IN WES

WES 的药物开发和生物多样性保护

• 批准号: 6078344
• 负责人: BRIAN G SCHUSTER
• 金额: $ 55万
• 依托单位: WALTER REED ARMY INSTITUTE OF RESEARCH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6078344
• 关键词: Africa; cooperative study; drug screening /evaluation; medicinal plants; plant ecology; plant extracts

West-central Africa contains the largest moist equatorial forest on the continent, indeed the second largest continuous tropical rain-forest in the world (3 million square km). The species richness of this region and its importance as a center for plant endemism makes it a key global center for biodiversity conservation. It is a unique area with great potential as a source of new molecular leads for drug development. The forest is currently facing major threats, including increased pressure from a growing human population and the destructive practices of logging and other commercial industry. This ICBG proposes to demonstrate that sustainable drug development is a viable alternative to such destructive activities as a source of income for local communities. This plan will encourage communities to protect their own resources. Our research design emphasizes the development of drugs for tropical diseases such as malaria and leishmaniasis as well as high-quality, affordable herbal medicines. We are also searching for new anti-HIV, anti-cancer and CNS drugs, as well as crop protection agents. The ICBG strategy is to use data from field ethnobotanical and ethnomedical surveys, plus biochemical information from the literature, to develop a prioritized list of plants for investigation. Such focus has been shown in our earlier work to markedly enhance the probability of discovering active lead compounds. We have established a 50-ha biodiversity plot in Cameroon as well as a network of 1-ha plots throughout Cameroon and Nigeria in unique vegetative zones in order to obtain long-term biological inventory and ecological dynamics data. A 50-ha plot in Nigeria is proposed in the present funding cycle. A database will link biochemical, ethnobotanical, economic and ecological data to allow the ICBG to determine the sustainability of long- term harvest of potentially valuable plants. Training, capacity building and infrastructure enhancement will be provided in all aspects of the project. The networks developed during the initial funding cycle will ensure that this project becomes a sustainable program which can operate and grow independently of this Group.

中西部非洲拥有世界上最大的潮湿赤道森林 大陆，实际上是世界上第二大连续热带雨林 世界(300万平方公里)。这一地区的物种丰富性和 它作为植物特有物种中心的重要性使其成为重要的全球中心 为了保护生物多样性。这是一个独特的领域，具有巨大的潜力 为药物开发提供新分子线索的来源。这片森林是 目前面临着重大威胁，包括来自 不断增长的人口和破坏性的伐木和 其他商业行业。 ICBG建议证明可持续药物开发是一种 替代这种破坏性活动作为收入来源的可行办法 为当地社区服务。这项计划将鼓励社区保护 他们自己的资源。我们的研究设计强调开发 治疗疟疾和利什曼病等热带疾病的药物以及 高品质、价格实惠的草药。我们还在寻找新的 抗艾滋病毒、抗癌和中枢神经系统药物，以及作物保护剂。 ICBG的战略是使用来自野外民族植物学和 民族医学调查，加上文献中的生化信息， 制定一份按优先顺序进行调查的植物清单。这样的关注具有 在我们早期的工作中已经显示出显著提高了 发现活泼的先导化合物。 我们在喀麦隆建立了一个50公顷的生物多样性地块，以及一个 在喀麦隆和尼日利亚的1公顷土地网络，以独特的植被 区域，以获得长期的生物清查和生态 动力学数据。目前的资金计划是在尼日利亚修建一块50公顷的地块。 周而复始。一个数据库将把生化、民族植物学、经济学和 生态数据，使ICBG能够确定长期- 有潜在价值的植物的定期收获。培训、能力建设 并将在各方面加强基础设施。 项目。在最初的筹资周期内建立的网络将 确保该项目成为一个可持续的、能够运作的计划 并独立于这一集团发展。