NURSING INTERVENTION TO IMPROVE ANTIVIRAL ADHERENCE

描述(改编自摘要)：首席调查员 建议对艾滋病毒进行前瞻性随机临床试验- 检测感染者(N=2000)居家治疗的效果 基于保乐成人教育原则的护理干预 Freire，旨在提高对高效抗逆转录病毒的依从性 治疗(HAART)。以骨骼为基础的护理干预将与 在非卧床护理环境中提供的标准护理。坚持不懈 结果将使用用药事件监控系统进行测量 (MEMS)数据、自我报告和未宣布的药片计数。实验 参与者将接受为期12周的家庭干预 每周，每隔一周，为期十二周，每月一年 之后。其他具体目标是：(1)描述关系 居家护理干预与生物措施的比较研究 临床结果(血浆定量HIV RNA水平和CD4淋巴细胞 计数)；(2)描述家庭护理与家庭护理 干预和临床结果的主观衡量(参与者的 对健康状况的感知)；以及(3)探索 居家护理干预效果及相关环境因素分析 忠诚度(社会支持、对提供者的信任以及对目标的了解 HAART)。数据收集方法包括面对面的访谈， 微型计算机监测技术、未公布的药片计数和医疗 在干预后6个月内记录基线摘要(月 18)。

DESCRIPTION (adapted from the Abstract): The Principal Investigator proposes to conduct a prospective randomized clinical trial of HIV- infected individuals (N=2000) to test the effectiveness of a home-based nursing intervention based on the adult education principles of Paole Freire and designed to improve adherence to highly active anti-retroviral therapies (HAART). The hone-based nursing intervention will be compared to standard nursing care provided in a ambulatory care setting. The adherence outcome will be measured using the medication event monitoring system (MEMS) data, self-report, and unannounced pill counts. Experimental participants will receive the home-based intervention weekly for twelve weeks, every other week for twelve weeks, and monthly for one year thereafter. Other specific aims are to: (1) describe the relationship between the home-based nursing intervention and biologic measures of clinical outcome (plasma quantitative HIV RNA levels and CD4 lymphocyte counts); (2) describe the relationship between the home-based nursing intervention and a subjective measure of clinical outcome (participant's perception of health stratus); and (3) explore the relationship between the home-based nursing intervention and contextual factors related to adherence (social support, trust in provider, and knowledge of the purpose of HAART). Data collections methods include face-to-face interviews, microcomputer monitoring technology, unannounced pill counts, and medical record abstraction at baseline through 6 months post intervention (Month 18).