NURSING INTERVENTION TO IMPROVE ANTIVIRAL ADHERENCE

提高抗病毒治疗依从性的护理干预

• 批准号: 2891295
• 负责人: Ann Bartley Williams
• 金额: $ 71.85万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891295
• 关键词: AIDS therapy; HIV infections; antiviral agents; behavioral /social science research tag; clinical research; clinical trials; health care service evaluation; health services research tag; helper T lymphocyte; home health care; human subject; interview; leukocyte count; nurse patient relations; nursing intervention; outcomes research; outpatient care; patient monitoring device; social support network; therapy compliance

DESCRIPTION (adapted from the Abstract): The Principal Investigator proposes to conduct a prospective randomized clinical trial of HIV- infected individuals (N=2000) to test the effectiveness of a home-based nursing intervention based on the adult education principles of Paole Freire and designed to improve adherence to highly active anti-retroviral therapies (HAART). The hone-based nursing intervention will be compared to standard nursing care provided in a ambulatory care setting. The adherence outcome will be measured using the medication event monitoring system (MEMS) data, self-report, and unannounced pill counts. Experimental participants will receive the home-based intervention weekly for twelve weeks, every other week for twelve weeks, and monthly for one year thereafter. Other specific aims are to: (1) describe the relationship between the home-based nursing intervention and biologic measures of clinical outcome (plasma quantitative HIV RNA levels and CD4 lymphocyte counts); (2) describe the relationship between the home-based nursing intervention and a subjective measure of clinical outcome (participant's perception of health stratus); and (3) explore the relationship between the home-based nursing intervention and contextual factors related to adherence (social support, trust in provider, and knowledge of the purpose of HAART). Data collections methods include face-to-face interviews, microcomputer monitoring technology, unannounced pill counts, and medical record abstraction at baseline through 6 months post intervention (Month 18).

描述（改编自摘要）：首席研究员 提议开展一项针对 HIV 的前瞻性随机临床试验 受感染个体（N = 2000）来测试基于家庭的有效性 基于保乐成人教育原则的护理干预 Freire 旨在提高高活性抗逆转录病毒药物的依从性 疗法（HAART）。将基于磨练的护理干预与 在门诊护理环境中提供标准护理。坚持性 将使用药物事件监测系统来测量结果 (MEMS) 数据、自我报告和未公布的药丸计数。实验性的 参与者将每周接受一次家庭干预，持续十二年 周，十二周内每隔一周一次，一年内每月一次 此后。其他具体目标是：（1）描述关系 家庭护理干预与生物措施之间的关系 临床结果（血浆定量 HIV RNA 水平和 CD4 淋巴细胞 计数）； (2)描述家庭护理之间的关系 干预和临床结果的主观测量（参与者的 对健康状况的感知）； (3)探索之间的关系 家庭护理干预和相关背景因素 遵守（社会支持、对提供者的信任以及对目的的了解） HAART）。资料收集方法包括面对面访谈、 微电脑监控技术、未公布的药丸计数和医疗 记录基线至干预后 6 个月的抽象情况（月 18）。