NURSING INTERVENTION TO IMPROVE ANTIVIRAL ADHERENCE

描述（改编自摘要）：主要研究者 计划进行一项前瞻性随机临床试验， 感染者（N=2000），以测试基于家庭的 基于保乐成人教育原则的护理干预 旨在提高对高效抗逆转录病毒药物的依从性 HAART（HAART）。将以蜂蜜为基础的护理干预与 在流动护理环境中提供的标准护理。粘附 将使用药物事件监测系统测量结局 （MEMS）数据，自我报告和未公布的药丸计数。实验 参与者将每周接受一次家庭干预， 每周，每隔一周十二周，每月一次，一年 然后其他具体目标是：（1）描述关系 家庭护理干预和生物措施之间的关系， 临床结局（血浆定量HIV RNA水平和CD 4淋巴细胞 （2）描述家庭护理与社区卫生服务的关系 干预和临床结果的主观测量（参与者的 （3）健康感知;（4）健康感知与健康感知之间的关系 家庭护理干预及相关背景因素 依从性（社会支持、对提供者的信任和对目的的了解 HAART）。数据收集方法包括面对面访谈， 微电脑监测技术，未公布的药丸计数，以及医疗 记录基线至干预后6个月的抽象（月 18）。

DESCRIPTION (adapted from the Abstract): The Principal Investigator proposes to conduct a prospective randomized clinical trial of HIV- infected individuals (N=2000) to test the effectiveness of a home-based nursing intervention based on the adult education principles of Paole Freire and designed to improve adherence to highly active anti-retroviral therapies (HAART). The hone-based nursing intervention will be compared to standard nursing care provided in a ambulatory care setting. The adherence outcome will be measured using the medication event monitoring system (MEMS) data, self-report, and unannounced pill counts. Experimental participants will receive the home-based intervention weekly for twelve weeks, every other week for twelve weeks, and monthly for one year thereafter. Other specific aims are to: (1) describe the relationship between the home-based nursing intervention and biologic measures of clinical outcome (plasma quantitative HIV RNA levels and CD4 lymphocyte counts); (2) describe the relationship between the home-based nursing intervention and a subjective measure of clinical outcome (participant's perception of health stratus); and (3) explore the relationship between the home-based nursing intervention and contextual factors related to adherence (social support, trust in provider, and knowledge of the purpose of HAART). Data collections methods include face-to-face interviews, microcomputer monitoring technology, unannounced pill counts, and medical record abstraction at baseline through 6 months post intervention (Month 18).