课题基金 / 基金详情

MOLECULAR MECHANISMS OF ESTROGEN INDUCED CARCINOGENESIS

MOLECULAR MECHANISMS OF ESTROGEN INDUCED CARCINOGENESIS
雌激素致癌的分子机制
批准号：
2633899
负责人：
HARI K BHAT
金额：
$10.18万
依托单位：
CHARLES R. DREW UNIVERSITY OF MED & SCI
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-01 至 2001-12-31
来源：
https://reporter.nih.gov/project-details/2633899
关键词：
animal genetic material tag carcinogenesis catechols clone cells complementary DNA estrogen receptors estrogens free radicals gene expression gene targeting hamsters hormone related neoplasm /cancer immunocytochemistry kidney neoplasms molecular cloning molecular oncology northern blottings protooncogene receptor expression transfection

项目摘要

项目成果

HARI K BHAT的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (Adapted from the applicant's abstract): The foundation for the proposed hypothesis of this application assumes three critical steps to carcinogenesis as studied in the Syrian hamster kidney tumor model: 1) hormonal stimulation, 2) metabolic activation, 3) free radical generation. The specific aims are to: 1) clone and characterize Syrian hamster ER cDNA; 2) study the effect of metabolic activation/free radical generation of ER gene expression; 3) characterize the role of metabolic/estrogenic potential on cell specific expression of ER proteins on tumorigenesis in hamster kidneys; and 4) investigate the role of metabolic activation of estrogens and the interdependency of, if any, between overexpression and neu suppression.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular Mechanisms & Importance of Oxidative Stress in Estrogen-Induced Carcino
Molecular Mechanisms & Importance of Oxidative Stress in Estrogen-Induced Carcino
Molecular Mechanisms & Importance of Oxidative Stress in Estrogen-Induced Carcino
Molecular Mechanisms & Importance of Oxidative Stress in Estrogen-Induced Carcino
海外基金