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MOLECULAR MECHANISMS OF ESTROGEN INDUCED CARCINOGENESIS

MOLECULAR MECHANISMS OF ESTROGEN INDUCED CARCINOGENESIS
雌激素致癌的分子机制
批准号：
6593011
负责人：
HARI K BHAT
金额：
$2.45万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-01 至 2002-12-31
来源：
https://reporter.nih.gov/project-details/6593011
关键词：
animal genetic material tag carcinogenesis catechols clone cells complementary DNA estrogen receptors estrogens free radicals gene expression gene targeting hamsters hormone related neoplasm /cancer immunocytochemistry kidney neoplasms molecular cloning molecular oncology northern blottings protooncogene receptor expression transfection

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中文摘要
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英文摘要
DESCRIPTION (Adapted from the applicant's abstract): The foundation for the proposed hypothesis of this application assumes three critical steps to carcinogenesis as studied in the Syrian hamster kidney tumor model: 1) hormonal stimulation, 2) metabolic activation, 3) free radical generation. The specific aims are to: 1) clone and characterize Syrian hamster ER cDNA; 2) study the effect of metabolic activation/free radical generation of ER gene expression; 3) characterize the role of metabolic/estrogenic potential on cell specific expression of ER proteins on tumorigenesis in hamster kidneys; and 4) investigate the role of metabolic activation of estrogens and the interdependency of, if any, between overexpression and neu suppression.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
Depletion of mitochondrial DNA and enzyme in estrogen-induced hamster kidney tumors: a rodent model of hormonal carcinogenesis.
雌激素诱导的仓鼠肾肿瘤中线粒体 DNA 和酶的消耗：激素致癌的啮齿动物模型。
DOI： 10.1002/jbt.10017
发表时间： 2002
期刊： Journal of biochemical and molecular toxicology.
影响因子： --
作者： [Bhat,HariK]
通讯作者： Bhat,HariK
TV parenting practices: is the same scale appropriate for parents of children of different ages?
DOI： 10.1186/1479-5868-10-41
发表时间： 2013-04-02
期刊： INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
影响因子： 8.7
作者： [Chen, Tzu-An, O'Connor, Teresia M., Baranowski, Tom]
通讯作者： Baranowski, Tom
Molecular Mechanisms & Importance of Oxidative Stress in Estrogen-Induced Carcino
Molecular Mechanisms & Importance of Oxidative Stress in Estrogen-Induced Carcino
Molecular Mechanisms & Importance of Oxidative Stress in Estrogen-Induced Carcino
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