SUBSTRATE UTILIZATION & AVAILABILITY ON EXERCISE STUDY IN HEART FAILURE

基材利用率

• 批准号: 6278869
• 负责人: DONNA M MANCINI
• 金额: $ 2.3万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278869
• 关键词: bioenergetics; carbohydrate biosynthesis; carbohydrate metabolism; clinical research; creatine phosphate; exercise; fatigue; glycogen; heart failure; human subject

It has been suggested that patients with heart failure may be more dependent on intramuscular substrates(phosphocreatine & glycogen) rather than blood borne metabolic fuels for skeletal muscle energy. This study attempts to examine how the combination of low intramuscular glycogen concentration, increased rate of glycogen utilization and altered glycogen repletion effects exercise performance ventilation and muscle fatigue in heart failure patients.

有人提出，心力衰竭患者可能更多地 依赖于肌内底物（磷酸肌酸和糖原），而不是 而不是血液中骨骼肌能量的代谢燃料本研究 试图研究低肌内糖原 浓度，增加糖原利用率和改变 糖原补充影响运动表现、通气和肌肉 心力衰竭患者的疲劳。