APAP-CR COMPARED TO TYLENOL ELIXIR IN FEBRILE CHILDREN

APAP-CR 与泰诺酏剂治疗发热儿童的比较

• 批准号: 6279157
• 负责人: BRETTEN D PICKERING
• 金额: $ 1.43万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279157
• 关键词: acetaminophen; antipyretic; blood chemistry; child (0-11); clinical research; drug administration rate /duration; human subject; hyperthermia; pediatric pharmacology; pharmacokinetics

Determine if ascent APAP-CR administered as a single dose for an 8 hour trial period is as efficacious and safe in reducing fever as children's tylenol elixir administered in 2 doses, one dose every 4 hours, in children with fever. Determine plasma levels of acetaminophen during the 10 hours following initial administration of the two formulations.

确定Ascant APAP-CR是否单次给药8小时 试用期与儿童退烧同样有效和安全 泰诺灵丹分两次服用，每4小时一次 发烧的孩子。测定受试者血浆中对乙酰氨基酚浓度 两种制剂首次给药后10小时。