APAP-CR COMPARED TO TYLENOL ELIXIR IN FEBRILE CHILDREN

APAP-CR 与泰诺酏剂治疗发热儿童的比较

• 批准号: 6117962
• 负责人: BRETTEN D PICKERING
• 金额: $ 1.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6117962
• 关键词: acetaminophen; antipyretic; blood chemistry; child (0-11); clinical research; drug administration rate /duration; human subject; hyperthermia; pediatric pharmacology; pharmacokinetics

Determine if ascent APAP-CR administered as a single dose for an 8 hour trial period is as efficacious and safe in reducing fever as children's tylenol elixir administered in 2 doses, one dose every 4 hours, in children with fever. Determine plasma levels of acetaminophen during the 10 hours following initial administration of the two formulations.

确定 ascent APAP-CR 是否以单剂量给药 8 小时 试用期与儿童退烧一样有效、安全 泰诺酏剂分 2 剂给药，每 4 小时 1 剂， 发烧的孩子。测定期间对乙酰氨基酚的血浆水平 初次施用两种制剂后10小时。