PATHOBIOLOGY OF DIGESTIVE DISEASES

消化系统疾病的病理学

• 批准号: 2733901
• 负责人: IRWIN Monroe ARIAS
• 金额: $ 30.6万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2733901
• 关键词: PATHOBIOLOGY; DIGESTIVE; DISEASES

A unique program is proposed to train pre- and postdoctoral PhD fellows for research careers in the pathobiology of digestive diseases, and to provide physicians with in-depth interdisciplinary training in modern biology as related to digestive disease pathobiology. Physicians spend three years in individualized research training, courses and laboratory rotations related to specific interests under supervision of an advisory committee. Training is supervised by 21 experienced preceptors associated with the Department of Physiology-Pathophysiology at Tufts University School of Medicine. Faculty are basic scientists and basically- oriented physician scientists who share enthusiasm for the proposed novel program and who have substantial research records and support in areas related to digestive diseases. The major research goal is to understand how events on the surface of cells (i.e., pumps, channels, receptors, etc.) control gene expression as related to signal transduction, regeneration, differentiation and polarity under physiologic conditions and in disease states. The program includes seminars, journal club and graduate courses including a unique program in Pathobiology for PhD Students and Fellows. Our goal is to bridge the gap between major advances in biology and their application to human digestive diseases. We seek to train PhD graduates and physicians who will work independently with clinical investigators rather than for them. The major goal is to reduce the intellectual barriers which separate basic scientists from their clinical colleagues and thereby enhance the transfer of knowledge from one discipline to another.

提出了一个独特的计划，以培养博士前和博士后博士 消化道疾病病理生物学研究员 疾病，并为医生提供深入的跨学科 与消化系统疾病相关的现代生物学培训 病理生物学医生们花了三年时间在个性化 研究培训、课程和实验室轮换， 在咨询委员会监督下的具体利益。 培训由21位经验丰富的导师监督， 塔夫茨大学生理病理生理学系 医学院的。教师是基础科学家，基本上- 导向的医生科学家谁分享的建议热情 新颖的计划，并有大量的研究记录和支持 与消化系统疾病有关的领域。主要研究目标是 为了理解细胞表面上的事件（即，泵， 通道、受体等）控制基因表达， 信号转导、再生、分化和极性 在生理条件下和在疾病状态下。程序 包括研讨会、期刊俱乐部和研究生课程， 为博士生和研究员提供病理生物学方面的独特课程。我们 目标是弥合生物学重大进展与 应用于人类消化系统疾病。我们寻求培养博士 毕业生和医生谁将独立与临床工作 调查员，而不是他们。主要目标是减少 将基础科学家与他们的 临床同事，从而提高知识的转移 从一个学科到另一个学科。