ENDOGENOUS SEROTONIN AND GUT TRANSPORT

内源性血清素和肠道运输

• 批准号: 2708045
• 负责人: MICHAEL C STONER
• 金额: $ 3.02万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2708045
• 关键词: calcitonin gene related peptide; chromaffin cells; gastrointestinal absorption /transport; gastrointestinal motility /pressure; human tissue; ion transport; radioimmunoassay; serotonin receptor; serotonin transporter; substance P; vasoactive intestinal peptide; voltage /patch clamp

Our laboratory is interested in the role of endogenous serotonin as it relates to gut transport and motility. We have extensive experience with a rat colon model, and plan to expand our work as follows: 1. We will characterize the release and transport response to endogenous 5-HT released via mucosal stimulation. 2. Based on the information learned using rat colon preparations we will delineate the function of physiologic 5-HT on human jejunum using novel isolated perfused tissue model. 3. Concurrently, we will study the effects of physiologic 5-HT on rat bowel transport and motility using an in situ animal model.

我们的实验室对内源性血清素的作用感兴趣 它与肠道运输和蠕动有关。 我们有广泛的 拥有大鼠结肠模型的经验，并计划将我们的工作扩展为 如下： 1. 我们将描述释放和运输响应 内源性5-HT通过粘膜刺激释放。 2. 根据使用大鼠结肠制剂获得的信息，我们 将描述生理性 5-HT 对人空肠的功能 使用新颖的分离灌注组织模型。 3. 同时，我们将研究生理性5-HT对 使用原位动物模型观察大鼠肠道运输和蠕动。