ENDOGENOUS SEROTONIN AND GUT TRANSPORT

内源性血清素和肠道运输

• 批准号: 2905172
• 负责人: MICHAEL C STONER
• 金额: $ 3.84万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2905172
• 关键词: calcitonin gene related peptide; chromaffin cells; gastrointestinal absorption /transport; gastrointestinal motility /pressure; human tissue; ion transport; radioimmunoassay; serotonin receptor; serotonin transporter; substance P; vasoactive intestinal peptide; voltage /patch clamp

Our laboratory is interested in the role of endogenous serotonin as it relates to gut transport and motility. We have extensive experience with a rat colon model, and plan to expand our work as follows: 1. We will characterize the release and transport response to endogenous 5-HT released via mucosal stimulation. 2. Based on the information learned using rat colon preparations we will delineate the function of physiologic 5-HT on human jejunum using novel isolated perfused tissue model. 3. Concurrently, we will study the effects of physiologic 5-HT on rat bowel transport and motility using an in situ animal model.

我们的实验室对内源性5-羟色胺的作用感兴趣， 它与肠道运输和运动有关。 我们有丰富 经验与大鼠结肠模型，并计划扩大我们的工作， 如下所示： 1. 我们将描述释放和运输反应， 通过粘膜刺激释放内源性5-HT。 2.基于使用大鼠结肠制备物获得的信息， 将描绘生理性5-HT对人空肠的作用 使用新的离体灌注组织模型。 3. 同时，我们将研究生理性5-HT对 使用原位动物模型的大鼠肠运输和运动。