PRESSURE AND FLOW INDUCED REMODELING OF CORONARY VESSELS

压力和流量诱导的冠状血管重塑

• 批准号: 2463142
• 负责人: GHASSAN S KASSAB
• 金额: $ 10.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-15 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2463142
• 关键词: angiogenesis; artery stenosis; blood flow measurement; blood pressure; collagen; coronary artery; disease /disorder model; elastin; hypertension; immunocytochemistry; mechanical stress; miniature swine; tissue engineering; vascular smooth muscle; ventricular hypertrophy

DESCRIPTION (Adapted from investigator's abstract): The objective of this proposal is to understand the adaptive mechanisms in the structure, mechanical properties and function of the coronary arterial vessels to altered mechanical forces, including principal and shear stresses, in experimental models of hypertension and flow overload. The specific aims include studies on alterations in the macro-structure including the length, diameter, and branching pattern of all generations of the coronary tree in response to increased mechanical stresses; alterations in the vessel walls and their micro-structure, including the intima, media and adventitia of all generations; to determine the remodeling of the mechanical properties, including the zero-stress state; and to express the structural and mechanical remodeling data mathematically in terms of indicial functions. This project will provide a structural and mechanical foundation for the study of tissue engineering of the blood vessels, to clarify the role of mechanical stresses on coronary blood vessel remodeling, and to clarify the structural and mechanical remodeling that signifies hypertension and hypertrophy as important risk factors for coronary artery disease.

描述（改编自研究者摘要）：本研究的目的 建议是了解结构中的适应机制， 冠状动脉血管的机械性能和功能， 改变的机械力，包括主应力和剪应力， 高血压和血流超负荷的实验模型。 具体目标 包括对宏观结构变化的研究，包括长度， 冠状动脉树的所有世代的直径和分支模式， 对机械应力增加的反应;血管壁的改变 以及它们的微结构，包括所有的内膜、中膜和外膜， 代;为了确定机械性能的重塑， 包括零应力状态;并表示结构和 机械重塑数据数学上的指数函数。 该项目将为以下项目提供结构和机械基础： 组织工程血管的研究，以阐明的作用， 机械应力对冠状血管重塑的影响，并阐明 结构和机械重塑表明高血压， 心肌肥厚是冠心病的重要危险因素。