NEUROPSYCHOLOGY OF PSYCHOSIS IN ALZHEIMERS DISEASE

阿尔茨海默病精神病的神经心理学

• 批准号: 2675448
• 负责人: Jane S Paulsen
• 金额: $ 14.11万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2675448
• 关键词: Alzheimer's disease; Lewy body; antipsychotic agents; behavioral genetics; clinical research; comorbidity; delusions; family genetics; frontal lobe /cortex; functional ability; hallucinations; human subject; human therapy evaluation; magnetic resonance imaging; mental disorder chemotherapy; mental disorder diagnosis; nervous system disorder chemotherapy; nervous system disorder diagnosis; neuropsychological tests; psychosis; remission /regression

DESCRIPTION (Adapted from applicant's abstract): The identification, diagnosis, and effective management of psychiatric symptoms in Alzheimer's Disease (AD) are critical to reduce the cost of health care, to increase practitioner efficiency and to improve the quality of life for AD patients and their caregivers. Until research finds a means of treating AD with curative measures, symptoms such as delusions and hallucinations must be aggressively identified, diagnosed, and managed. Although recent research has shown a high prevalence of psychosis in AD and has implicated a worse prognosis for those AD patients with psychosis, the risk factors for and underlying mechanisms of psychosis in AD are poorly understood. The proposed project will be the first study to prospectively investigate the neuropsychologic factors associated with psychosis in AD. With the aim of exploring the heterogeneity of behavioral presentation and course in AD, the proposed studies are designed to prospectively compare the neuropsychological performances of AD patients who develop psychosis with AD patients who do not develop psychosis. Furthermore, the current proposal will retrospectively analyze the neuropsychological performances of AD patients currently enrolled in the research centers at UCSD who are identified as having psychosis.

描述（根据申请人的摘要改编）：标识， 诊断和有效管理阿尔茨海默氏症的精神病症状 疾病（AD）对于降低医疗保健成本至关重要 从业者效率并提高广告患者的生活质量 和他们的照顾者。 直到研究找到一种处理广告的方法 治愈措施，妄想和幻觉等症状必须是 积极识别，诊断和管理。 虽然最近的研究 在AD中表现出高度的精神病患病率，并暗示更糟 那些患有精神病的广告患者的预后，危险因素和 广告中精神病的潜在机制知之甚少。 这 拟议项目将是第一项前瞻性研究的研究 与AD中的精神病相关的神经心理因素。 目的 探索行为表现和AD中的过程的异质性， 拟议的研究旨在前瞻性地比较 通过AD发展精神病的AD患者的神经心理表现 不发展精神病的患者。 此外，当前的建议 将回顾性分析AD的神经心理学表现 目前正在加州大学UCSD研究中心的患者 被确定为精神病。