STRUCTURAL MRI IMAGING IN HUNTINGTON'S DISEASE

亨廷顿病的结构 MRI 成像

• 批准号: 7604830
• 负责人: Jane S Paulsen
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604830
• 关键词: Brain; Cognition; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Disease; Funding; Gene Mutation; Grant; Huntington Disease; Individual; Institution; Investigation; Iowa; Magnetic Resonance Imaging; Pattern; Research; Research Personnel; Resources; Site; Source; Structure; United States National Institutes of Health; Universities; cerebral atrophy; software development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous research with magnetic resonance imaging (MRI) has indicated that brain atrophy occurs in specific regions prior to Huntington's disease (HD) diagnosis in individuals who have the HD gene mutation. As the disease progresses, brain atrophy spreads to other regions, though the advancing pattern of brain atrophy is not well-characterized. We are currently leading a longitudinal multi-site investigation of brain structure and cognition in presymptomatic HD which will help us to delineate brain changes that occur before people are diagnosed with HD. By using sophisticated software developed at the University of Iowa, we will anlayze MRI scans of 20 individuals who have the gene mutation for HD and who have been diagnosed with the disease. This will allow us to better characterize the progression of brain atrophy throughout the course of the disease.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 先前的磁共振成像（MRI）研究表明，在患有亨廷顿舞蹈病（HD）基因突变的个体中，在亨廷顿病（HD）诊断之前，脑萎缩发生在特定区域。 随着疾病的进展，脑萎缩会扩散到其他区域，尽管脑萎缩的进展模式还没有得到很好的表征。 我们目前正在领导一项对症状前HD的大脑结构和认知的纵向多站点调查，这将有助于我们描绘在人们被诊断患有HD之前发生的大脑变化。 通过使用爱荷华州大学开发的复杂软件，我们将分析20名患有HD基因突变并被诊断患有该疾病的人的MRI扫描。 这将使我们能够更好地描述整个疾病过程中脑萎缩的进展。