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M CSF AND THE PATHOGENESIS OF ATHEROSCLEROSIS

M CSF AND THE PATHOGENESIS OF ATHEROSCLEROSIS
M CSF 与动脉粥样硬化的发病机制
批准号:
2609329
负责人:
Tripathi Byasmuni Rajavashisth
金额:
$10.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-12-01 至 2000-11-30

项目摘要

项目成果

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中文摘要
翻译
这项建议的长远目标是增加我们对……的了解
英文摘要
The long range goal of this proposal is to increase our understanding of the mechanisms involved in the pathogenesis of atherosclerosis. Atherosclerotic lesions contain elevated levels of macrophage-colony stimulating factor (M-CSF or CSF-1). The presence of M-CSF in the normal artery correlates with an increase in the arterial lesion suggesting that M-CSF may contribute significantly to the initiation and/or progression of atherosclerosis by affecting monocyte-mac ophage function and survival in the artery wall. Our previous studies indicate that induced expression of M-CSF at focal sites within the artery wall may be one link among the injurious effects of various atherogenic agents. The overall objectives of these studies are to extend our work using combined biochemical and molecular genetic approaches to investigate the mechanisms involved in the vascular injury-induced expression of M-CSF, and to examine the aspects of the mechanisms through which M-CSF participates in the pathogenesis of atherosclerosis. The specific aims include 1) to investigate the effects of M-CSF on its own expression and the expression of its receptor and several other cytokines and growth factors using cultured human artery wall cells, 2) to use in vitro mutagenesis and transient expression assays to identify the cis-acting DNA elements involved in the vascular injury-induced or autoinduced upregulation of the human M-CSF gene, 3) to test the M-CSF cis-acting DNA elements for binding to specific nuclear proteins and identify trans- acting factors that participate in the vascular injury-mediated transcriptional activation, 4) to use mouse model of arterial injury to examine the induced expression of M-CSF and its receptor in vivo, and 5) to investigate the effects of M-CSF ont he growth of arterial lesion- associated cells in vivo using osteopetrotic (op/op) mice that totally lack M-CSF and apolipoprotein E (apoE)-deficient mice that exhibit accelerated atherosclerosis. The proposed experiments will provide important information that will enhance our understanding of the role of M-CSF in the pathogenesis of atherosclerosis, and may prove valuable in developing ways to control the disease.
期刊论文(18)
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会议论文
Multinucleated giant cells in atherosclerotic plaques of human carotid arteries: Identification of osteoclast-like cells and their specific proteins in artery wall.
人颈动脉粥样硬化斑块中的多核巨细胞:动脉壁中破骨细胞样细胞及其特异性蛋白质的鉴定。
DOI: 10.1016/j.yexmp.2015.11.010
发表时间: 2015
期刊: Experimental and molecular pathology
影响因子: 3.6
作者: [Qiao,Jian-Hua, Mishra,Vivek, Fishbein,MichaelC, Sinha,SatyeshK, Rajavashisth,TripathiB]
通讯作者: Rajavashisth,TripathiB
Increased expression of macrophage colony-stimulating factor after coronary artery balloon injury is inhibited by intracoronary brachytherapy.
冠状动脉球囊损伤后巨噬细胞集落刺激因子表达的增加被冠状动脉内近距离放射治疗所抑制。
DOI: 10.1161/01.cir.0000016048.03020.6c
发表时间: 2002
期刊: Circulation
影响因子: 37.8
作者: [Finkelstein,Ariel, Makkar,Raj, Doherty,TerenceM, Vegesna,VijayaR, Tripathi,Pinky, Liu,Ming, Bergman,Jonathan, Fishbein,Michael, Hausleiter,Joerg, Takizawa,Kaname, Rukshin,Vladimir, Shah,PredimanK, Rajavashisth,TripathiB]
通讯作者: Rajavashisth,TripathiB
DOI: --
发表时间: 1997-05
期刊: The American journal of pathology
影响因子: --
作者: [J. Qiao;Jagannath Tripathi;N. Mishra;Y. Cai;S. Tripathi;X. Wang;S. Imes;Michael C Fishbein;Steven K. Clinton;Peter Libby;A. Lusis;T. Rajavashisth]
通讯作者: J. Qiao;Jagannath Tripathi;N. Mishra;Y. Cai;S. Tripathi;X. Wang;S. Imes;Michael C Fishbein;Steven K. Clinton;Peter Libby;A. Lusis;T. Rajavashisth
DOI: 10.1096/fj.02-0913hyp
发表时间: 2003-04-01
期刊: FASEB JOURNAL
影响因子: 4.8
作者: [Doherty, TM, Shah, PK, Rajavashisth, TB]
通讯作者: Rajavashisth, TB
10
    M-CSF ISOFORMS IN ATHEROSCLEROSIS
    • 批准号:
      2692327
    • 项目类别:
    • 资助金额:
      $21.11万
    • 财政年份:
      1998
    • 负责人:
      Tripathi Byasmuni Rajavashisth
    • 依托单位:
    M-CSF ISOFORMS IN ATHEROSCLEROSIS
    • 批准号:
      6030830
    • 项目类别:
    • 资助金额:
      $21.74万
    • 财政年份:
      1998
    • 负责人:
      Tripathi Byasmuni Rajavashisth
    • 依托单位:
    M-CSF ISOFORMS IN ATHEROSCLEROSIS
    • 批准号:
      6389692
    • 项目类别:
    • 资助金额:
      $23.07万
    • 财政年份:
      1998
    • 负责人:
      Tripathi Byasmuni Rajavashisth
    • 依托单位:
    M-CSF ISOFORMS IN ATHEROSCLEROSIS
    • 批准号:
      6184012
    • 项目类别:
    • 资助金额:
      $22.4万
    • 财政年份:
      1998
    • 负责人:
      Tripathi Byasmuni Rajavashisth
    • 依托单位:
    海外基金