课题基金 / 基金详情

M-CSF ISOFORMS IN ATHEROSCLEROSIS

M-CSF ISOFORMS IN ATHEROSCLEROSIS
动脉粥样硬化中的 M-CSF 异构体
批准号:
6184012
负责人:
Tripathi Byasmuni Rajavashisth
金额:
$22.4万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-07-10 至 2002-06-30

项目摘要

项目成果

Tripathi Byasmuni Rajavashisth的其他基金

相似基金

相关文献

中文摘要
翻译
描述(改编自研究者摘要):的总体目标
英文摘要
DESCRIPTION (Adapted from Investigator's Abstract): The overall goal of this research is to understand the etiologic role of macrophage colony-stimulating factor (M-CSF) in atherosclerosis. Accumulating evidence suggests that M-CSF by influencing the recruitment, growth, survival and function of monocyte-macrophages, may contribute importantly to the promotion of atherosclerosis. Supporting this conclusion are this laboratory's recent findings showing that absence of M-CSF in apolipoprotein (apo) E or low density lipoprotein receptor-deficient mice significantly reduces atherosclerosis despite augmented hypercholesterolemia. The mechanism(s) underlying the causal role of M-CSF in atherosclerosis is not known, but may involve specific isoforms of M-CSF whose biological effects are mediated by a single receptor. The overall hypothesis is that augmented expression of tissue associated M-CSF isoforms in response to atherogenic stimuli in the vessel wall and bone marrow plays a critical role in the development of atheromatous lesions. To test aspects of this hypothesis, studies are proposed with the following specific aims: 1) to study the effects of M-CSF deficiency in the vessel wall on the development of arterial lesions by transplanting wild type. bone marrow cells into mice lacking both M-CSF and apoE and to determine by immunological assays which isoforms of M-CSF are expressed by vascular cells in the normal vessel and during atherogenesis in apo-E null mice; 2) to perform in vitro studies using cultured vascular cells from humans and osteopetrotic (op/op) mice to examine the mechanism(s) underlying the M-CSF mediated growth and activation of monocytes and intimal smooth muscle cells; 3) to produce transgenic mice expressing only the mM-CSF isoform on an op/op genetic background and to examine the effects of the mM-CSF on atherogenesis either by feeding the transgenic mice a high fat, high cholesterol diet or by crossing them with apo E-null mice to generate compound mutants expressing mM-CSF on an atherogenic background. These studies may provide new and exciting information that might prove valuable in the rational design of novel therapeutic interventions for atherosclerosis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
M-CSF ISOFORMS IN ATHEROSCLEROSIS
  • 批准号:
    2692327
  • 项目类别:
  • 资助金额:
    $21.11万
  • 财政年份:
    1998
  • 负责人:
    Tripathi Byasmuni Rajavashisth
  • 依托单位:
M-CSF ISOFORMS IN ATHEROSCLEROSIS
  • 批准号:
    6030830
  • 项目类别:
  • 资助金额:
    $21.74万
  • 财政年份:
    1998
  • 负责人:
    Tripathi Byasmuni Rajavashisth
  • 依托单位:
M-CSF ISOFORMS IN ATHEROSCLEROSIS
  • 批准号:
    6389692
  • 项目类别:
  • 资助金额:
    $23.07万
  • 财政年份:
    1998
  • 负责人:
    Tripathi Byasmuni Rajavashisth
  • 依托单位:
M CSF AND THE PATHOGENESIS OF ATHEROSCLEROSIS
  • 批准号:
    2609329
  • 项目类别:
  • 资助金额:
    $10.35万
  • 财政年份:
    1994
  • 负责人:
    Tripathi Byasmuni Rajavashisth
  • 依托单位:
海外基金