SOCIODEMOGRAPHIC REGULATION OF CV FUNCTION AND STRUCTURE

CV功能和结构的社会人口调节

• 批准号: 2750568
• 负责人: Frank A Treiber
• 金额: $ 29.12万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750568
• 关键词: African American; adolescence (12-20); behavioral /social science research tag; cardiovascular disorder epidemiology; cardiovascular function; caucasian American; clinical research; environmental adaptation; human subject; interview; racial /ethnic difference; socioeconomics; socioenvironment; stimulus /response; stress; twin /multiplet; vascular resistance

DESCRIPTION: The purpose of the proposed research is to establish the aspects of ethnicity that are associated with the differential expression of cardiovascular disease processes in African Americans and Caucasian Americans. Given increasing awareness of the extent to which environments typically faced by these ethnic groups differ, environmental influence on these processes may be an important factor that is an aspect of ethnicity. Socioeconomic status (SES) is a useful index of such environments and is associated with cardiovascular disease (CVD). Since behavior is one pathway through which SES influences are thought to be expressed in disease, this proposal focuses specifically on stress responsivity, which is thought to be linked to the pathophysiology of CVD. Since such disease has its antecedents in childhood, a multiethnic pediatric sample will be employed. In addition, the subject sample will consist of twins. Investigation of the impact of environments on the expression of CVD can be achieved only with proper control for biological influences. Four hundred and eighty twin pairs will visit the laboratory. Half of the pairs will be Africa American, and half Caucasian American; and male and females will be equally represented. Subjects will complete three laboratory stressors: a video game task, a structured social interview, and the cold pressor. Stress responsivity will be assessed, with particular interest being paid to systemic vascular resistance (SVR). Left ventricular mass (LVM) will also be assessed. Sophisticated environmentally and genetically informative analyses will permit quantification of environmental impact upon SVR responsivity and LVM. It is hypothesized that environmental influences (SES) will account for a greater proportion of the variance in SVR responsivity and LVM in African Americans than Caucasian Americans. The hypothesis that SVR responsivity is a pathway through which SES exerts its influence on LVM will also be tested. The long-term objectives are to provide a better understanding of environmental influences on CVD which will aid in the development of improved primary prevention programs.

描述：拟议研究的目的是建立 种族方面，与差异表达相关， 非裔美国人和高加索人的心血管疾病进程 美国人 鉴于人们日益认识到环境 这些族群所面临的典型差异、环境影响 这些过程可能是一个重要因素，是族裔的一个方面。 社会经济地位（SES）是这种环境的一个有用指标， 与心血管疾病（CVD）有关。 因为行为是一种 社会经济地位的影响被认为是通过疾病表达的， 建议特别关注压力反应，这被认为是 与CVD的病理生理学有关。 由于这种疾病有其 在童年的前因，将采用多种族的儿科样本。 此外，受试者样本将由双胞胎组成。 调查 环境对CVD表达的影响只能通过 适当控制生物影响。 480对双胞胎将参观实验室。 半年 对将是非洲裔美国人，一半是高加索裔美国人;男性和 女性将得到平等的代表。 受试者将完成三个 实验室压力源：视频游戏任务，结构化社交面试， 冷加压。 将评估压力反应，特别是 对体循环血管阻力（SVR）的关注。 左室 还将评估质量（LVM）。 先进的环境和 遗传信息分析将允许量化的环境 影响SVR响应度和LVM。 据推测，环境 影响（SES）将占方差的更大比例， 非裔美国人的SVR反应性和LVM高于白人美国人。 的 假设SVR反应性是SES发挥其 也将测试对LVM的影响。 长期目标是更好地了解 环境对CVD的影响，这将有助于发展 改善初级预防方案。