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CALPAIN SYSTEM IN HEALTH AND DISEASE

CALPAIN 系统在健康和疾病中的应用

基本信息

批准号：
2840887
负责人：
DARREL E GOLL
金额：
$ 1.5万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-06-01 至 2000-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2840887
关键词：
X ray crystallography calpain cataract enzyme activity enzyme structure eye disorder ischemia isozymes meeting /conference /symposium muscular dystrophy nervous system disorder pathologic process protein structure function travel

项目摘要

Support is requested for a FASEB Summer Symposium "The Calpain System in Health and Disease", to be held at Copper Mountain, Colorado, June 20 to 25, 1999. The calpains are intracellular calcium-dependent proteases which are emerging as regulators of several important cellular functions and participators in initiation and progression of pathologic states. This conference will be the first opportunity for the growing number of calpain investigators in academia and industry to meet in a setting which will foster the exchange of ideas and development of collaborations. Participants will include many pioneering calpain researchers as well as young investigators who have recently begun active research in this area. Topics will include: 1) X-ray crystallographic analysis of calpain structure; 2) discussion of the phylogenically diverse calpain gene family members, and their physiologic functions; 3) mechanisms for regulation of calpain activities in cells; 4) physiologic functions of the ubiquitous calpain isoforms found in animal cells; and 5) the roles of the calpains in diverse pathologies including muscular dystrophies, neurologic diseases, ischemic damage, and cataracts. Funding is requested to partially support travel expenses and housing for speakers, organizers and promising young investigators. Additional funding will be sought from the Muscular Dystrophy Association, and the USDA, because of calpain involvement in muscular dystrophy and muscle growth. Funding will also be requested from several drug companies which are currently conducting research on calpains. In selecting participants, preference will be given to women and under- represented minorities. The speakers include virtually all of the woman scientists in the field who have made substantial contributions. Two of the session chairs are women. The Copper Mountain resort is a handicapped-accessible facility, and the registration form will question participants about any special needs they may have.

要求支助将于1999年6月20日至25日在科罗拉多铜山举行的美国生物安全协会夏季专题讨论会“保健和疾病中的钙蛋白酶系统”。钙蛋白酶是一种细胞内钙依赖性蛋白酶，参与多种重要的细胞功能的调节和病理状态的发生和发展。这次会议将是学术界和工业界越来越多的calpain研究人员在一个环境中见面的第一次机会，这将促进思想交流和合作的发展。与会者将包括许多开创性的钙蛋白酶研究人员以及最近开始在这一领域积极研究的年轻研究人员。主题包括：1）钙蛋白酶结构的X射线晶体学分析; 2）钙蛋白酶基因家族成员的遗传多样性及其生理功能的讨论; 3）细胞中钙蛋白酶活性的调节机制; 4）动物细胞中普遍存在的钙蛋白酶异构体的生理功能;和5）钙蛋白酶在多种病理学中的作用，包括肌营养不良、神经系统疾病、缺血性损伤和白内障。要求提供部分资金，以支付演讲者、组织者和有前途的年轻调查员的旅费和住房。由于钙蛋白酶参与肌营养不良和肌肉生长，将从肌营养不良协会和美国农业部寻求额外的资金。目前正在进行钙蛋白酶研究的几家制药公司也将要求提供资金。在挑选与会者时，将优先考虑妇女和代表人数不足的少数群体。演讲者几乎包括该领域做出重大贡献的所有女科学家。两名会议主席是女性。铜山度假村是一个残疾人无障碍设施，登记表将询问参与者他们可能有什么特殊需要。