MOLECULAR BIOLOGY OF AUTOANTIBODIES

自身抗体的分子生物学

• 批准号: 2879627
• 负责人: Eng M TAN
• 金额: $ 0.5万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2879627
• 关键词: autoantibody; autoimmune disorder; immunoregulation; meeting /conference /symposium; molecular biology; travel

In the rheumatic diseases, there is a subgroup of illnesses which are sometimes called systemic rheumatic diseases and includes systemic lupus erythematosus, scleroderma, Sjogren's syndrome, mixed connective tissue disease, dermatomyositis and polymyositis, rheumatoid arthritis and drug-induced lupus. This subgroup is characterized by the presence of autoantibodies to nuclear and cytoplasmic autoantigens. Each of the diseases described above has a different profile of autoantibodies and there is now much evidence to show that the autoantibody response is antigen-driven. Molecular characterization of the structure and function of antigens has proceeded at a rapid pace, due to contributions from Immunologists and Molecular and Cell Biologists. However, the crucial question of why and how intracellular molecules become immunogenic has not been elucidated. One hypothesis is that autoantigens are rendered immunogenic because of mutations, alterations in structure and function, altered expression, or ectopic distribution - all of which are related to altered antigen as the driving principle behind the autoantibody response. Since 1989, there have been a series of Workshops on the Molecular and Cell Biology of Autoantibodies and Autoimmunity which started at the University of Heidelberg in Germany and has been held every two years in different institutions throughout the world. These workshops have encouraged closer contacts between Immunologists on the one hand and Molecular and Cell Biologists on the other and have been successful in promoting collaboration between these two groups of scientists. The aim is to facilitate greater interaction between these scientists and immunologists by face-to-face scientific exchanges and to address the clinically important question of the immunogenicity of autoantigens.

在风湿性疾病中，有一个亚组的疾病， 有时称为系统性风湿性疾病，包括系统性狼疮 红斑，硬皮病，干燥综合征，混合性结缔组织 疾病，皮肌炎和多发性肌炎，类风湿性关节炎， 药物引起的狼疮 该亚组的特征在于存在 针对细胞核和细胞质自身抗原的自身抗体。 每个 上述疾病具有不同的自身抗体谱， 现在有很多证据表明，自身抗体反应是 抗原驱动 结构的分子表征和 抗原的功能进展迅速，由于贡献 来自免疫学家和分子与细胞生物学家。 但 细胞内分子为什么以及如何成为 免疫原性尚未阐明。 一种假设是， 由于自身抗原的突变、改变 在结构和功能，改变表达，或异位分布- 所有这些都与作为驱动原理的改变的抗原有关 自身抗体反应的背后 自1989年以来，有一系列 自身抗体的分子和细胞生物学研讨会， 自体免疫起源于德国的海德堡大学 每两年在不同的机构举行一次， 世界 这些讲习班鼓励了 一方面是免疫学家，另一方面是分子和细胞生物学家。 并成功地促进了这些组织之间的合作。 两组科学家。 目的是促进更多的互动 这些科学家和免疫学家之间通过面对面的科学 交流和解决临床上重要的问题， 自身抗原的免疫原性。