SLEEP APNEA IN A NON-CLINICAL POPULATION

非临床人群的睡眠呼吸暂停

• 批准号: 2854275
• 负责人: Jerome A Dempsey
• 金额: $ 7.2万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2854275
• 关键词: age difference; aging; clinical research; computer assisted diagnosis; computer data analysis; epidemiology; human data; human old age (65+); polysomnography; respiratory airflow disorder; sleep apnea

A large unique data-set has been obtained between 1988 and 1998 in a population of 1400 workers age 30 to 60 years, including an overnight sleep polysomnographic in-lab study conducted on two occasions over an eight year period. We wish to use the statistical power provided by computerized analysis of over 300,000 apneas and hypopneas in this non- clinical population. Our five specific aims are concerned with the causes, consequences and quantitation of sleep disordered breathing (SDB). 1. What are the physiologic characteristics of SDB events in the non-clinical population in terms of severity, high airway resistance, obstructive and central components and associated after- effects on EEG arousal and ventilatory overshoots? Do these important elements of the SDB event change as SDB progresses over time? Do the ventilatory or cardiovascular consequences of apnea or hypopnea and its immediate aftermath determine the likelihood of subsequent sleep- disordered breathing events? 2. What are the immediate and long-term cardiovascular consequences of sleep-disordered breathing events; what characteristics of these SDB events (such as O2 desaturation, arousal, ventilatory overshoot airway resistance, etc.) determine the cardiovascular responses and consequences? 3. What is the effect of aging on SDB and its sequelae as studied in the truly healthy elderly? 4. What role do anatomical characteristics of the upper airway play in determining the frequency and severity I and type of sleep-disordered breathing? Do these anatomical determinants differ in the general non- clinical population versus the obstructive sleep apnea (OSA) population? ... in the obese versus the non-obese? 5. To thoroughly evaluate our computerized analysis of SDB events in order to determine their accuracy and specificity for purposes of quantation and categorization of SDB events.

在1988年至1998年期间， 1400名年龄在30至60岁的工人，包括一个通宵 睡眠多导睡眠描记实验室研究进行了两次， 八年期间。 我们希望利用统计力量， 在这个非- 临床人群。我们的五个具体目标涉及 睡眠呼吸障碍的原因、后果和量化 （SDB）。 1. SDB事件的生理特征是什么？ 非临床人群在严重程度、高气道 阻力、阻塞性和中枢成分以及相关的后- 对脑电唤醒和兴奋过度的影响 做这些重要的 随着时间的推移，SDB事件的要素会发生变化？ 做 呼吸暂停或呼吸不足的呼吸或心血管后果及其 直接的后果决定了随后睡眠的可能性- 呼吸紊乱事件 2. 什么是短期和长期 睡眠呼吸障碍事件的心血管后果;什么 这些SDB事件的特征（例如O2去饱和，觉醒， 呼吸道阻力过冲等）确定 心血管反应和后果？3. 效果如何 在真正健康的老年人中研究的SDB衰老及其后遗症？ 4. 上呼吸道的解剖特征在 确定睡眠障碍的频率和严重程度I以及类型 呼吸？这些解剖决定因素是否在一般非- 临床人群与阻塞性睡眠呼吸暂停（OSA）人群？ ...肥胖者和非肥胖者之间的差异5.全面评估我们的 对SDB事件进行计算机分析，以确定其准确性 和特异性，用于SDB的定量和分类 事件