SLEEP APNEA IN A NON-CLINICAL POPULATION

非临床人群的睡眠呼吸暂停

• 批准号: 6184719
• 负责人: Jerome A Dempsey
• 金额: $ 7.2万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6184719
• 关键词: age difference; aging; clinical research; computer assisted diagnosis; computer data analysis; epidemiology; human data; human old age (65+); polysomnography; respiratory airflow disorder; sleep apnea

A large unique data-set has been obtained between 1988 and 1998 in a population of 1400 workers age 30 to 60 years, including an overnight sleep polysomnographic in-lab study conducted on two occasions over an eight year period. We wish to use the statistical power provided by computerized analysis of over 300,000 apneas and hypopneas in this non- clinical population. Our five specific aims are concerned with the causes, consequences and quantitation of sleep disordered breathing (SDB). 1. What are the physiologic characteristics of SDB events in the non-clinical population in terms of severity, high airway resistance, obstructive and central components and associated after- effects on EEG arousal and ventilatory overshoots? Do these important elements of the SDB event change as SDB progresses over time? Do the ventilatory or cardiovascular consequences of apnea or hypopnea and its immediate aftermath determine the likelihood of subsequent sleep- disordered breathing events? 2. What are the immediate and long-term cardiovascular consequences of sleep-disordered breathing events; what characteristics of these SDB events (such as O2 desaturation, arousal, ventilatory overshoot airway resistance, etc.) determine the cardiovascular responses and consequences? 3. What is the effect of aging on SDB and its sequelae as studied in the truly healthy elderly? 4. What role do anatomical characteristics of the upper airway play in determining the frequency and severity I and type of sleep-disordered breathing? Do these anatomical determinants differ in the general non- clinical population versus the obstructive sleep apnea (OSA) population? ... in the obese versus the non-obese? 5. To thoroughly evaluate our computerized analysis of SDB events in order to determine their accuracy and specificity for purposes of quantation and categorization of SDB events.

在1988年至1998年期间获得了大量独特的数据集