CONFERENCE ON CHEMOKINES AND CHEMOKINE RECEPTORS

趋化因子和趋化因子受体会议

• 批准号: 2758899
• 负责人: STEPHEN W HUNT
• 金额: $ 0.15万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2758899
• 关键词: chemokine; cytokine receptors; meeting /conference /symposium; travel

Chemokines are a superfamily of chemoattractant proteins originally identified as key mediators of leukocyte trafficking. These proteins have been linked to a wide variety of acute and chronic inflammatory processes and more recently, cancer and infectious disease. Several chemokine receptors are now known to serve as essential co-receptors for HIV infection. The list of chemokines and chemokine receptors continues to grow largely through to the application of genomics technologies. In vitro and in vivo models are providing valuable insights into the function of these chemokines in normal cellular processes and their involvement in disease. Molecular approaches have provided information on chemokine structure-function, mechanisms of signal transduction and transcriptional regulation. Efforts in the pharmaceutical sector are producing inhibitors of chemokine function. The aim of this meeting is to bring together an international group of experts to discuss recent advances in the biology of chemokines and their role in human disease.

趋化因子最初是化学引诱蛋白的一个超家族 被鉴定为白细胞运输的关键介质。这些蛋白质 与多种急性和慢性炎症有关， 过程，最近，癌症和传染病。 几 现在已知趋化因子受体作为必需的共受体， 艾滋病毒感染。 趋化因子和趋化因子受体的列表继续 通过基因组学技术的应用， 体外和体内模型提供了有价值的见解 这些趋化因子在正常细胞过程中的功能及其 参与疾病。 分子方法提供了信息， 趋化因子的结构-功能，信号转导机制， 转录调控 制药部门的努力是 产生趋化因子功能抑制剂。 这次会议的目的是 召集一个国际专家小组讨论最近的 趋化因子的生物学进展及其在人类疾病中的作用。