CONFERENCE ON CHEMOKINES AND CHEMOKINE RECEPTORS

趋化因子最初是趋化蛋白的超家族。 被确认为白细胞贩运的关键调解人。这些蛋白质 与各种急性和慢性炎症性疾病有关 过程，以及最近的癌症和传染病。几个 趋化因子受体现在被认为是重要的辅助受体 艾滋病毒感染。趋化因子和趋化因子受体的清单还在继续 主要发展到基因组学技术的应用。 体外和体内模型提供了对 这些趋化因子在正常细胞过程中的作用及其机制 与疾病有关的。分子方法提供了信息 趋化因子的结构与功能、信号转导机制及作用机制 转录调控。制药部门的努力是 产生趋化因子功能的抑制剂。这次会议的目的是 召集一个国际专家组讨论最近的 趋化因子生物学及其在人类疾病中作用的研究进展。

Chemokines are a superfamily of chemoattractant proteins originally identified as key mediators of leukocyte trafficking. These proteins have been linked to a wide variety of acute and chronic inflammatory processes and more recently, cancer and infectious disease. Several chemokine receptors are now known to serve as essential co-receptors for HIV infection. The list of chemokines and chemokine receptors continues to grow largely through to the application of genomics technologies. In vitro and in vivo models are providing valuable insights into the function of these chemokines in normal cellular processes and their involvement in disease. Molecular approaches have provided information on chemokine structure-function, mechanisms of signal transduction and transcriptional regulation. Efforts in the pharmaceutical sector are producing inhibitors of chemokine function. The aim of this meeting is to bring together an international group of experts to discuss recent advances in the biology of chemokines and their role in human disease.