课题基金 / 基金详情

RELATIONSHIP BETWEEN TUMOR PO2 & MR QUANTIFIED ADC: RAT BRAIN

RELATIONSHIP BETWEEN TUMOR PO2 & MR QUANTIFIED ADC: RAT BRAIN
肿瘤 PO2 之间的关系
批准号:
6123368
负责人:
Jeffrey Frank Dunn
金额:
$0.65万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-15 至 1999-08-31

项目摘要

项目成果

Jeffrey Frank Dunn的其他基金

相关文献

中文摘要
翻译
肿瘤氧合是治疗和肿瘤的重要变量 表现出广泛的氧气张力。我们假设 ADC的无创性磁共振成像可能有助于肿瘤的评估 小鼠模型的氧合作用及其与肿瘤氧分压的相关性。这个 ADC部分与细胞内/细胞外体积有关。在以下情况下 慢性缺氧,但在弗兰克坏死发生之前,细胞可能 由于离子调节受损而肿胀。这将导致一个 降低了ADC。在RIF-1肿瘤中确定了这种关系, 根据假设,ADC随血氧分压的增加而增加。
英文摘要
Tumor oxygenation is an important variable in treatment and tumors exhibit a wide range of oxygen tensions. We hypothesized that non-invasive MR imaging of the ADC may be useful for assessing tumor oxygenation and correlated ADC with tumor pO2 in mouse models. The ADC relates in part to intra/extracellular volume. In cases of chronic hypoxia, but before frank necrosis has occured, the cells may swell due to impaired ion regulation. This would result in a decreased ADC. The relationship was determined in RIF-1 tumors and, as hypothesized, the ADC was found to increase with increasing pO2.
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会议论文
2022 In Vivo Magnetic Resonance Gordon Research Conference and Gordon Research Seminar
  • 批准号:
    10611143
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2022
  • 负责人:
    Jeffrey Frank Dunn
  • 依托单位:
Development and validation of a multimodal MRI/near-infrared spectroscopysystem to study brain oxidative metabolism in mouse models of neurologicaldisease
  • 批准号:
    9326993
  • 项目类别:
  • 资助金额:
    $14.74万
  • 财政年份:
    2016
  • 负责人:
    Jeffrey Frank Dunn
  • 依托单位:
In vivo studies of cerebral angiogenesis and oxygenation
  • 批准号:
    6723490
  • 项目类别:
  • 资助金额:
    $19.98万
  • 财政年份:
    2004
  • 负责人:
    Jeffrey Frank Dunn
  • 依托单位:
In vivo studies of cerebral angiogenesis and oxygenation
  • 批准号:
    7271985
  • 项目类别:
  • 资助金额:
    $18.94万
  • 财政年份:
    2004
  • 负责人:
    Jeffrey Frank Dunn
  • 依托单位: