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RELATIONSHIP BETWEEN TUMOR PO2 & MR QUANTIFIED ADC: RAT BRAIN

RELATIONSHIP BETWEEN TUMOR PO2 & MR QUANTIFIED ADC: RAT BRAIN
肿瘤 PO2 之间的关系
批准号：
6123368
负责人：
Jeffrey Frank Dunn
金额：
$0.65万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-15 至 1999-08-31
来源：
https://reporter.nih.gov/project-details/6123368
关键词：
Mammalia bioengineering /biomedical engineering biomaterials biomedical resource gas neoplasm /cancer nuclear magnetic resonance spectroscopy technology /technique

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英文摘要
Tumor oxygenation is an important variable in treatment and tumors exhibit a wide range of oxygen tensions. We hypothesized that non-invasive MR imaging of the ADC may be useful for assessing tumor oxygenation and correlated ADC with tumor pO2 in mouse models. The ADC relates in part to intra/extracellular volume. In cases of chronic hypoxia, but before frank necrosis has occured, the cells may swell due to impaired ion regulation. This would result in a decreased ADC. The relationship was determined in RIF-1 tumors and, as hypothesized, the ADC was found to increase with increasing pO2.
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