HETEROGENEITY OF BRAIN OXYGENATION
HETEROGENEITY OF BRAIN OXYGENATION
批准号:
6353201
负责人:
Jeffrey Frank Dunn
金额:
$1.22万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-01 至 2002-04-30
中文摘要
由于某些未知的原因,LiPc晶体在
一些特定的条件。例如,众所周知,这些晶体
在纯净水和大脑中几个月后对氧气敏感
但在肌肉中,它们在几天内就会对氧气失去敏感性。Dr。
Sutcliffe观察到LiPc在使用时明显不稳定,但它
不清楚这是否只是由于LiPC的质量所致
他。在英国食品研究所的研究中,它是
发现了锂酞菁的氧敏性质
当放置在不同类型的
石油。因此,系统地研究了LiPc晶体的稳定性
在葵花籽油中使用了具有良好特性的LiPc。五
来自两个不同批次的晶体被放置在特氟龙试管中
装满了葵花籽油。三个晶体(来自一批)具有
在第一天和第二天,对氧气的敏感度相同
几个月后。两个LiPc晶体(来自不同的批次)只有
第一天的敏感度减半,完全没有敏感度
两个月后。这项实验表明,我们还没有完全
了解影响人民币汇率稳定的因素
LiPc晶体的氧敏特性。虽然这是
有问题,这也带来了希望,有了这样的理解,我们可能
能够进一步提高它们在肌肉等组织中的稳定性
目前,它们不能超过几天的使用。
英文摘要
For some unknown reasons LiPc crystals are not very stable under
certain conditions. For example it is well known that these crystals
are sensitive to oxygen after a few months in pure water and in brain
but in a muscle lose their sensitivity to oxygen in a few days. Dr.
Sutcliffe observed apparent instability of LiPc when in use but it was
not clear if this was due only to the quality of the LiPc available to
him. In studies at the Institute of Food Research in the U.K., it was
found that the oxygen sensitive properties of lithium phthalocyanine
appeared to vary more than expected when placed in different types of
oils. Therefore a systematic study of the stability of LiPc crystals
in sunflower oil was undertaken using well characterized LiPc. Five
crystals from two different batches were placed in a Teflon tube
filled with sunflower oil. Three crystals (from one batch) had the
same and the usual sensitivity to oxygen on the first day and two
months later. Two LiPc crystals (from a different batch) had only
half of the sensitivity on the first day and no sensitivity at all
after two months. This experiment indicates that we do not yet fully
understand the factors which affect the stability of the
oxygen-sensitive properties of LiPc crystals. While this is
problematic, it also raises hope that with such understanding, we may
be able to improve further their stability in tissues such as muscles
where currently they cannot be used for more than a few days.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
2022 In Vivo Magnetic Resonance Gordon Research Conference and Gordon Research Seminar
-
批准号:10611143
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2022
-
负责人:Jeffrey Frank Dunn
-
依托单位:
Development and validation of a multimodal MRI/near-infrared spectroscopysystem to study brain oxidative metabolism in mouse models of neurologicaldisease
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批准号:9326993
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项目类别:
-
资助金额:$14.74万
-
财政年份:2016
-
负责人:Jeffrey Frank Dunn
-
依托单位:
In vivo studies of cerebral angiogenesis and oxygenation
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批准号:6723490
-
项目类别:
-
资助金额:$19.98万
-
财政年份:2004
-
负责人:Jeffrey Frank Dunn
-
依托单位:
In vivo studies of cerebral angiogenesis and oxygenation
-
批准号:7271985
-
项目类别:
-
资助金额:$18.94万
-
财政年份:2004
-
负责人:Jeffrey Frank Dunn
-
依托单位:
In vivo studies of cerebral angiogenesis and oxygenation
-
批准号:7488554
-
项目类别:
-
资助金额:$18.94万
-
财政年份:2004
-
负责人:Jeffrey Frank Dunn
-
依托单位:
In vivo studies of cerebral angiogenesis and oxygenation
-
批准号:6949665
-
项目类别:
-
资助金额:$19.51万
-
财政年份:2004
-
负责人:Jeffrey Frank Dunn
-
依托单位:
Near infrared/MR system for imaging brain oxygenation
-
批准号:6326330
-
项目类别:
-
资助金额:$38.81万
-
财政年份:2001
-
负责人:Jeffrey Frank Dunn
-
依托单位:
Near infrared/MR system for imaging brain oxygenation
-
批准号:6540065
-
项目类别:
-
资助金额:$35.78万
-
财政年份:2001
-
负责人:Jeffrey Frank Dunn
-
依托单位:
Near infrared/MR system for imaging brain oxygenation
-
批准号:6615724
-
项目类别:
-
资助金额:$35.78万
-
财政年份:2001
-
负责人:Jeffrey Frank Dunn
-
依托单位:
BLOOD OXYGEN LEVEL DEPENDENT (BOLD) MR IMAGING & BRAIN OXYGEN TENSION
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批准号:6353202
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项目类别:
-
资助金额:$1.22万
-
财政年份:2000
-
负责人:Jeffrey Frank Dunn
-
依托单位:
7T NMR CONSOLE
-
批准号:6053071
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项目类别:
-
资助金额:$31.9万
-
财政年份:2000
-
负责人:Jeffrey Frank Dunn
-
依托单位:
NON INVASIVE MR LOCALIZATION OF OXYGEN SENSITIVE EPR MATERIALS
-
批准号:6353198
-
项目类别:
-
资助金额:$0.61万
-
财政年份:2000
-
负责人:Jeffrey Frank Dunn
-
依托单位:
EFFECT OF CHRONIC HYPOXIA ON BRAIN OXYGENATION
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批准号:6353200
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项目类别:
-
资助金额:$1.22万
-
财政年份:2000
-
负责人:Jeffrey Frank Dunn
-
依托单位:
BOLD MR IMAGING OF TUMOR OXYGEN TENSION
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批准号:6315314
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项目类别:
-
资助金额:$9.12万
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财政年份:2000
-
负责人:Jeffrey Frank Dunn
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依托单位:
CORRELATING EPR OXIMETRY WITH METABOLISM AND PHYSIOLOGY
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批准号:6315318
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项目类别:
-
资助金额:$9.12万
-
财政年份:2000
-
负责人:Jeffrey Frank Dunn
-
依托单位:
CRITICAL PO2 IN BRAIN
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批准号:6353199
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项目类别:
-
资助金额:$0.61万
-
财政年份:2000
-
负责人:Jeffrey Frank Dunn
-
依托单位:
NMR & EPR STUDIES OF BOLD CONTRAST & OXYGENATION IN TUMORS
-
批准号:6353197
-
项目类别:
-
资助金额:$1.22万
-
财政年份:2000
-
负责人:Jeffrey Frank Dunn
-
依托单位:
BOLD MR IMAGING OF TUMOR OXYGEN TENSION
-
批准号:6107721
-
项目类别:
-
资助金额:$9.12万
-
财政年份:1999
-
负责人:Jeffrey Frank Dunn
-
依托单位:
BLOOD OXYGEN LEVEL DEPENDENT (BOLD) MR IMAGING & BRAIN OXYGEN TENSION
-
批准号:6206528
-
项目类别:
-
资助金额:$1.22万
-
财政年份:1999
-
负责人:Jeffrey Frank Dunn
-
依托单位:
NON INVASIVE MR LOCALIZATION OF OXYGEN SENSITIVE EPR MATERIALS
-
批准号:6206524
-
项目类别:
-
资助金额:$0.61万
-
财政年份:1999
-
负责人:Jeffrey Frank Dunn
-
依托单位:
海外基金