TEMPORAL CONSIDERATIONS IN DYNAMIC SPIRAL BREAST MRI

动态螺旋乳腺 MRI 中的时间考虑因素

• 批准号: 6282957
• 负责人: YI-FEN YEN
• 金额: $ 2.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282957
• 关键词: biomedical resource; female; human subject; magnetic resonance imaging; radiology; technology /technique

Introduction: An analytical method is presented to determine the temporal resolution and dynamic scan duration necessary in the Gd-enhanced dynamic breast MR imaging without compromising the diagnostic efficacy of dynamic images. Methods: The Gd-enhanced signal time curves of various temporal resolutions and scan durations are simulated by manipulating existing patient data. The simulated time curves are fitted by a two-compartment pharmacokinetic model to determine K21 and wash-out slope parameters. The diagnostic efficacy of dynamic images with reduced temporal resolutions and shorter scan durations is tested by ROC analyses of K21 and wash-out slope parameters from simulated time curves. Results: The results suggest that temporal resolution of a few seconds is most desirable and the scan duration is not critical to the diagnostic efficacy of dynamic scan using K21 and wash-out slope if the dynamic scan is long enough to observe the Gd uptake period. However, the fitting for the wash-out slope becomes unstable in short time series. This presents a potential problem in pixel-by-pixel fitting to obtain parametric images using dynamic data of short scans. Conclusions: The analysis presented here can be used to guide researchers in a choice of optimized scan strategy.

引言：提出了一种分析方法来确定 时间分辨率和动态扫描持续时间， Gd增强动态乳腺MR成像，不影响 动态图像的诊断效果。 方法：钆增强 各种时间分辨率和扫描持续时间的信号时间曲线 通过操纵现有的患者数据来模拟。 模拟 通过二室药代动力学模型拟合时间曲线， 确定K21和冲刷斜率参数。 的诊断有效性 具有降低的时间分辨率和更短的扫描时间的动态图像 通过K21和洗脱斜率的ROC分析来检验持续时间 模拟时间曲线的参数。 结果：结果表明， 几秒钟的时间分辨率是最理想的， 扫描持续时间对动态心电图的诊断效果并不重要 如果动态扫描足够长，则使用K21和洗脱斜率进行扫描 观察Gd摄取期。 然而， 冲刷坡在短时间序列中变得不稳定。 这提出了一个 在逐像素拟合以获得参数 图像使用短扫描的动态数据。 结论：分析 这里提出的可以用来指导研究人员在选择 优化扫描策略。