MULTI-EXCITATION NON-CPMG WITH LOW FLIP ANGLES FOR HYPERPOLARIZED 13C MRS

用于超极化 13C MRS 的低翻转角多激励非 CPMG

• 批准号: 8362970
• 负责人: YI-FEN YEN
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362970
• 关键词: Annual Reports; Cell Nucleus; Funding; Future; Grant; Image; Magnetic Resonance; Maps; National Center for Research Resources; Phase; Physiologic pulse; Principal Investigator; Reading; Relaxation; Reporting; Research; Research Infrastructure; Resources; Rotation; Scheme; Signal Transduction; Source; Techniques; Technology; Test Result; Testing; Time; Training; United States National Institutes of Health; Variant; Visit; abstracting; cost; design; spectroscopic imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We report a new MR spectroscopic imaging sequence that utilizes non-CPMG1,2 FSE echo trains with quadratic phase modulation of the refocusing pulses to catalyze the stability of longitudinal magnetization while keeping the transverse magnetization refocused during the echo train. Other alternative phase modulation schemes (XY, MLEV ) are useful only over a very restricted range, close to ¿, of the refocusing pulse rotation angle (nutation)1. The non-CPMG phase scheme performs well for nutations as low as 160¿ and with a proper design of RF pulses of wide bandwidth, this technique can be quite suitable for fast spectroscopic imaging. Because non-CPMG allows us to obtain a full magnitude signal even in the presence of initial phase variation, we can perform multiple low flip-angle excitations with FSE readouts without waiting for the longitudinal signal to recover via T1 relaxation, a condition ideal for spectroscopic imaging of hyperpolarized nuclei. In this report, we show preliminary test results of multi-excitation non-CPMG with low flip angles (MENLO) and one of its potential applications for mapping T2 relaxation time. The tests were performed on a 13C-enriched phantom, with imaging parameters suitable for future hyperpolarized 13C applications. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们报告了一种新的磁共振波谱成像序列，它利用具有二次相位的非CPMG1，2 FSE回波序列 调制重聚焦脉冲以在保持横向磁化的同时催化纵向磁化的稳定性 磁化作用在回声列车中重新聚焦。其他可选的相位调制方案(XY、MLEV)仅有用 在一个非常有限的范围内，接近于重聚焦脉冲的旋转角(章动)1.非CPMG相位方案 对于低至160°的章动性能良好，并且通过适当设计宽带宽的RF脉冲，该技术可以 非常适合快速光谱成像。因为非CPMG允许我们获得完整的幅度信号，即使在 在存在初始相位变化的情况下，我们可以使用FSE读数执行多个低翻转角激励，而无需等待 通过T1弛豫恢复纵向信号，这是超极化原子核光谱成像的理想条件。在……里面 本文给出了低翻转角多励磁非CPMG(Menlo)及其其中一种的初步试验结果。 T2弛豫时间图的潜在应用。这些测试是在一个富含13C的体模上进行的，并进行了成像 适用于未来超极化13C应用的参数。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/(卢卡斯年度报告和 ISMRM 2011年摘要)