GENDER DEVELOPMENT IN INTERSEXUAL PATIENTS

双性患者的性别发展

• 批准号: 2863486
• 负责人: AMY B WISNIEWSKI
• 金额: $ 3.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2863486
• 关键词: adrenal hyperplasia; androgens; clinical research; hormone regulation /control mechanism; human subject; interview; pseudohermaphroditism; questionnaires; reproductive system surgery; sex development disorder; sex differentiation

DESCRIPTION The proposed research will examine gender development in adult intersexual patients. Gender development will be assessed through the use of questionnaires and psychological interviews. Information from these questionnaires and interviews will be analyzed in concert with extent of early androgen exposure, endocrine treatment outcome of the intersexual patients. Lastly, parents of intersexual patients will be questioned concerning the medical decisions they made relating to their child's treatment. Participants will be selected from patients treated for congenital adrenal hyperplasia (CAH) or 46,XY pseudohermaphroditism in the Pediatric Endocrine Clinical at John Hopkins Hospital from 1943 to 1998. This group of intersex patients is one of the largest identified groups available in the United States, and many of these individuals have already been located for previous investigation conducted by Dr. Migeon. This research will broaden our understanding of gender development among intersexual patients while controlling for etiology and treatment (both endocrine and surgical), and may provide useful information regarding the current dispute over appropriate guidelines for medical treatment of intersexual children.

描述 这项拟议中的研究将研究成年中间性人的性别发展情况。 患者性别发展将通过使用 问卷调查和心理访谈。这些信息 调查问卷和访谈将与以下方面的程度进行分析： 早期雄激素暴露，内分泌治疗结果的中间性 患者最后，中间性患者的父母将被询问 关于他们对孩子的医疗决定， 治疗将从接受以下治疗的患者中选择参与者： 先天性肾上腺皮质增生（CAH）或46，XY假两性畸形， 1943年至1998年在约翰霍普金斯医院儿科内分泌临床。 这群阴阳人患者是最大的已确定群体之一 在美国，许多人已经 在Migeon博士之前进行的研究中找到。这 研究将扩大我们对性别发展的理解， 中间性患者，同时控制病因和治疗（两者） 内分泌和外科），并可提供有关 目前关于治疗老年痴呆症的适当准则的争议 中间性儿童