GENDER DEVELOPMENT IN INTERSEXUAL PATIENTS

双性患者的性别发展

• 批准号: 6363371
• 负责人: AMY B WISNIEWSKI
• 金额: $ 4.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6363371
• 关键词: adrenal hyperplasia; androgens; clinical research; hormone regulation /control mechanism; human subject; interview; pseudohermaphroditism; questionnaires; reproductive system surgery; sex development disorder; sex differentiation

DESCRIPTION The proposed research will examine gender development in adult intersexual patients. Gender development will be assessed through the use of questionnaires and psychological interviews. Information from these questionnaires and interviews will be analyzed in concert with extent of early androgen exposure, endocrine treatment outcome of the intersexual patients. Lastly, parents of intersexual patients will be questioned concerning the medical decisions they made relating to their child's treatment. Participants will be selected from patients treated for congenital adrenal hyperplasia (CAH) or 46,XY pseudohermaphroditism in the Pediatric Endocrine Clinical at John Hopkins Hospital from 1943 to 1998. This group of intersex patients is one of the largest identified groups available in the United States, and many of these individuals have already been located for previous investigation conducted by Dr. Migeon. This research will broaden our understanding of gender development among intersexual patients while controlling for etiology and treatment (both endocrine and surgical), and may provide useful information regarding the current dispute over appropriate guidelines for medical treatment of intersexual children.

描述 拟议的研究将检查成年间性人的性别发展 患者。性别发展将通过使用 问卷调查和心理访谈。来自这些的信息 将根据调查问卷和访谈的程度进行分析 早期雄激素暴露、间性人内分泌治疗结果 患者。最后，双性恋患者的父母将受到质疑 关于他们做出的有关孩子的医疗决定 治疗。参与者将从接受治疗的患者中选出 先天性肾上腺增生症 (CAH) 或 46,XY 假两性畸形 1943 年至 1998 年在约翰·霍普金斯医院从事儿科内分泌临床工作。 这组双性人患者是最大的已确定群体之一 在美国可用，其​​中许多人已经 Migeon 博士之前进行的调查已找到。这 研究将加深我们对性别发展的理解 双性恋患者，同时控制病因和治疗（两者 内分泌和外科），并可能提供有关 当前关于适当医疗指南的争议 间性儿童。

项目成果

Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Growth, development, and therapeutic considerations.

由于 21-羟化酶缺乏而导致的先天性肾上腺增生。

• DOI: 10.1016/s0889-8529(08)70026-4
• 发表时间: 2001
• 期刊: Endocrinology and metabolism clinics of North America.
• 作者: Migeon,CJ;Wisniewski,AB
• 通讯作者: Wisniewski,AB

Gender identity/role differentiation in adolescents affected by syndromes of abnormal sex differentiation.

受性别分化异常综合征影响的青少年的性别认同/角色分化。

• 发表时间: 2002
• 期刊: Adolescent medicine (Philadelphia, Pa.)
• 作者: Wisniewski,AmyB;Migeon,ClaudeJ
• 通讯作者: Migeon,ClaudeJ

Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats.

• DOI: 10.1097/01.ju.0000046780.23389.e0
• 发表时间: 2003-04
• 期刊: The Journal of urology
• 作者: A. Wisniewski;S. Klein;Y. Lakshmanan;J. Gearhart

46,XY intersex individuals: phenotypic and etiologic classification, knowledge of condition, and satisfaction with knowledge in adulthood.

46,XY 双性人：表型和病因学分类、状况知识以及成年期对知识的满意度。

• DOI: 10.1542/peds.110.3.e32
• 发表时间: 2002
• 期刊: Pediatrics
• 影响因子: 8
• 作者: Migeon,ClaudeJ;Wisniewski,AmyB;Brown,TerryR;Rock,JohnA;Meyer-Bahlburg,HeinoFL;Money,John;Berkovitz,GaryD
• 通讯作者: Berkovitz,GaryD

Complete androgen insensitivity syndrome: long-term medical, surgical, and psychosexual outcome.

完全雄激素不敏感综合征：长期的医疗、手术和性心理结果。

• DOI: 10.1210/jcem.85.8.6742
• 发表时间: 2000
• 期刊: The Journal of clinical endocrinology and metabolism.
• 作者: Wisniewski,AB;Migeon,CJ;Meyer-Bahlburg,HF;Gearhart,JP;Berkovitz,GD;Brown,TR;Money,J
• 通讯作者: Money,J