INCREASING F & V INTAKE IN HEAD & NECK CANCER PATIENTS

描述(申请人的描述)早期头颈癌 似乎接受治疗的患者，经历了高发病率和 年癌症复发和第二原发癌的死亡率 癌变领域。水果和蔬菜的摄入量一直较低 被发现是头颈癌的危险因素有证据表明 与患第二原发癌的风险较高有关。来自Head和的数据 一项正在进行的临床试验表明，这些患者 患者不会显著增加他们相对较低的水果摄入量 以及被诊断为癌症后的蔬菜摄入量，而且大多数 保持在远低于美国国家推荐的每天5份的摄入量 每天吃大量的水果和蔬菜。该项目的目的是确定 如果使用基于阶段变化的量身定做的干预模式 会增加水果和蔬菜的供应量，从而增加 血浆类胡萝卜素水平提高30%。干预措施将被设计成 可以翻译成这些患者的正常医疗护理。 该州80例早期头颈癌患者 康涅狄格州将被招募参与这项研究。病人报告摄入量 每天少于5份的水果和蔬菜将被随机分配到 要么是研究的干预部门，要么是对照部门。那些生活在 干预手臂将接受量身定做的干预，旨在增加 水果和蔬菜的摄入量基于他们被分配的阶段成员资格 关于水果和蔬菜的摄入量。将进行干预 在6个月的期限内，将包括每6周一次的联系人，这将模仿 这些患者的后续护理计划。审判的结果 将通过测量血浆类胡萝卜素水平的变化来评估 干预组与对照组相比的试验持续时间 一群人。如果可行，这种干预可以纳入日常护理。 对于这些患者来说，可以降低他们患后续癌症的风险。

DESCRIPTION (Applicant's Description) Early stage head and neck cancer patients, who appear curatively treated, experience high morbidity and mortality rates from both cancer recurrence and second primary cancers in the field of cancerization. Low fruit and vegetable intake has consistently been found to be a risk factor for head and neck cancer evidence suggests an association with a higher risk of second primary cancer. Data from head and neck cancer patients in an ongoing clinical trial suggests that these patients do not significantly increase their relatively low intake of fruit and vegetable intake following diagnosis of cancer, and that the majority remain well below the US nationally recommended daily intake of 5 servings of fruits and vegetables per day. The aim of this project is to determine if the use of a tailored intervention based on the stage of change model will increase their servings of fruit and vegetables and thereby increase plasma carotenoid levels by 30 percent. The intervention will be designed to be translatable to the normal medical care of these patients. Eighty patients with early stage head and neck cancer from the State of Connecticut will be recruited for the study. Patients reporting intake of less than 5 daily servings of fruit and vegetables will be randomized to either the intervention or control arm of the study. Those in the intervention arm will receive a tailored intervention designed to increase intake of fruit and vegetables based on their assigned stage membership with regard to fruit and vegetable intake. The intervention will be conducted over a 6 month period and will include a contact every 6 weeks which mimics the follow up care schedule for these patients. The outcome of the trial will be assessed by measuring the change in plasma carotenoid levels over the length of the trial in the intervention group as compared to the control group. If feasible this intervention could be incorporated into usual care for these patients to reduce their risk of subsequent cancer.