INCREASING F & V INTAKE IN HEAD & NECK CANCER PATIENTS

增加F

• 批准号: 2895999
• 负责人: Brenda Cartmel
• 金额: $ 18.16万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2895999
• 关键词: behavioral /social science research tag; carotene; clinical research; clinical trials; counseling; fruit; head /neck neoplasm; human subject; human therapy evaluation; neoplasm /cancer nutrition therapy; nutrient intake activity; nutrition related tag; vegetables

DESCRIPTION (Applicant's Description) Early stage head and neck cancer patients, who appear curatively treated, experience high morbidity and mortality rates from both cancer recurrence and second primary cancers in the field of cancerization. Low fruit and vegetable intake has consistently been found to be a risk factor for head and neck cancer evidence suggests an association with a higher risk of second primary cancer. Data from head and neck cancer patients in an ongoing clinical trial suggests that these patients do not significantly increase their relatively low intake of fruit and vegetable intake following diagnosis of cancer, and that the majority remain well below the US nationally recommended daily intake of 5 servings of fruits and vegetables per day. The aim of this project is to determine if the use of a tailored intervention based on the stage of change model will increase their servings of fruit and vegetables and thereby increase plasma carotenoid levels by 30 percent. The intervention will be designed to be translatable to the normal medical care of these patients. Eighty patients with early stage head and neck cancer from the State of Connecticut will be recruited for the study. Patients reporting intake of less than 5 daily servings of fruit and vegetables will be randomized to either the intervention or control arm of the study. Those in the intervention arm will receive a tailored intervention designed to increase intake of fruit and vegetables based on their assigned stage membership with regard to fruit and vegetable intake. The intervention will be conducted over a 6 month period and will include a contact every 6 weeks which mimics the follow up care schedule for these patients. The outcome of the trial will be assessed by measuring the change in plasma carotenoid levels over the length of the trial in the intervention group as compared to the control group. If feasible this intervention could be incorporated into usual care for these patients to reduce their risk of subsequent cancer.

描述（申请人的描述）早期头颈癌 出现治愈性治疗的患者的发病率较高， 癌症复发和第二原发癌症的死亡率， 癌变领域。 水果和蔬菜摄入量低一直是 被发现是头颈癌的危险因素，证据表明， 与第二原发癌的高风险相关。 数据来自头部和 一项正在进行的临床试验表明， 患者不会显著增加其相对较低的水果摄入量 和蔬菜的摄入量，而大多数 仍远低于美国国家推荐的每日5份摄入量 每天的水果和蔬菜。 本项目的目的是确定 如果使用基于变革阶段模型的定制干预措施， 会增加他们的水果和蔬菜的份量， 血浆类胡萝卜素水平下降30% 干预将被设计为 to be translatable翻译to the normal正常medical医疗care护理of these patients病人. 80名来自美国的早期头颈癌患者， 康涅狄格州将被招募参加这项研究。 报告摄入以下药物的患者 每天少于5份的水果和蔬菜将被随机分配到 研究的干预组或对照组。 那些在 干预组将接受专门干预， 水果和蔬菜的摄入量根据其分配的阶段成员， 注意水果和蔬菜的摄入。 干预将在 在6个月的时间内，将包括每6周联系一次， 这些患者的后续护理计划。 审判结果 将通过测量血浆类胡萝卜素水平的变化来评估， 与对照组相比，干预组的试验持续时间 组 如果可行的话，这种干预可以纳入日常护理 以降低他们患后续癌症的风险。