OUTCOME OF PRETERM SMALL FOR GESTATIONAL AGE ADOLESCENTS

候选人是一名儿科医生，拥有妇幼保健硕士学位。她是高危儿童和儿童发育随访诊所的主治医生。她已经开始了科学工作，并建立了与她的特殊兴趣有关的关系，了解与怀孕有关的和围产期事件对儿童生长发育的长期结果的影响。她的近期目标是通过增加她对高危儿童和青少年神经发育评估的知识，并通过在大型数据库统计分析和生长曲线分析方面获得更多的培训，开发一个关于低出生体重婴儿长期结果的系统研究项目。这些知识将帮助她发展设计和开展多中心临床试验的能力，管理大型数据库以及设计有用的研究结果测量方法来评估大人群的发展结果。她描述了一个教学课程和具体的咨询，以实现这一知识。在UAB现有的多学科基础设施中，她将特别与公民国际研究中心合作，这是一个专门研究儿童发展和结果评估的中心。她将与她研究领域的几位资深教师专家合作。拟议的项目是一项前瞻性纵向研究，将评估参加连续小于胎龄（SGA）研究的早产儿的长期结果，该研究是NICHD赞助的一项研究，该研究招募了来自单个县的有宫内发育迟缓（IUGR）风险的多胎低收入孕妇。这些妇女和她们的婴儿在产前、出生时以及1岁和5岁时都被跟踪。本研究的总体假设是，与适宜孕龄（AGA）早产儿相比，SGA早产儿的生长发育会受到损害。在控制了产后变量后，生长和发育结果将与产前和围产期变量相关。该研究将包括出生在1986年至1988年之间的99名早产儿（<37周妊娠）SGA和121名早产儿AGA。这些儿童在评估时将是11至13岁。所有参与者将通过人体测量、骨骼质量发展、身体组成（双能x线骨密度测量和骨龄）和性成熟来评估生长。发展评估将包括评估学业成就、认知分数、学习障碍评估、行为和功能结果工具。本研究为了解IUGR后出生的儿童的长期预后及其与产前和围产期事件的关系提供了重要信息。

The candidate is a Pediatrician with an MPH in maternal and child health. She is an attending physician in clinics for follow-up of high-risk children and child development. She has begun scientific work and established relationships related to her special interests on understanding the impact of pregnancy-related and perinatal events on the long-term outcome for child growth and development. Her immediate goals are to develop a systematic program of research on the long-term outcomes of low birth weight infants, by increasing her knowledge of assessments of neurodevelopment of children and adolescents at risk, and by obtaining more training in statistical analysis of large databases and growth curve analysis. This knowledge will assist her to develop her ability to design and conduct multi-center clinical trials, to manage large databases and to design useful research outcome measurements for evaluating developmental outcomes in large populations. She describes a didactic curriculum and specific consultations to achieve this knowledge. Within the multidisciplinary infrastructure, existing at UAB she will work in particular with the Civitan International Research Center, a center specialized in development and outcome assessments of children. She will be working with several senior faculty experts in her area of research. The proposed project is a prospective longitudinal study that will assess the long-term outcomes of preterm children who participated in the Successive Small for Gestational Age (SGA) Study, an NICHD sponsored study, that recruited multiparous low-income pregnant women at risk for Intrauterine Growth Retardation (IUGR) from a single county. These women and their infants were followed antenatally, at birth and at 1 and 5 years of age. The overall hypothesis of this proposed study is that growth and development of preterm SGA adolescents will be impaired compared to preterm Appropriate for Gestational Age (AGA) children. Growth and developmental outcomes will correlate with prenatal and perinatal variables after controlling for postnatal variables.The study will include 99 preterm (<37 weeks gestation) SGA and 121 preterm AGA children who were born between 1986 and 1988. These children will be 11 to 13 years at the time of the assessments. All participants will be assessed for growth using anthropometric measures, development of skeletal mass, body composition (dual energy X-Ray absorptiometry and bone age), and sexual maturation. Developmental assessment will include assessing academic achievement, cognitive scores, assessment of learning disabilities, behavioral and functional outcome instruments. This study should provide important information to understand the longterm outcomes for children who were born after IUGR and its relationship with prenatal and perinatal events.