HEALthy Brain and Child Development Study at UAB and UA

UAB 和 UA 的健康大脑和儿童发展研究

• 批准号: 10380426
• 负责人: Ada Myriam Peralta-Carcelen
• 金额: $ 114.01万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10380426
• 关键词: Academic Medical Centers; Address; Adolescence; Affect; Alabama; Alcohols; Area; Award; Basic Science; Behavioral; Biological; Birth; Brain; Brain imaging; Center for Translational Science Activities; Child; Child Development; Childhood; Clinic; Clinical Research; Cognitive; Collaborations; Communities; County; Data; Data Collection; Databases; Development; Discipline of obstetrics; Drug Exposure; Electroencephalography; Endocrine system; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Evaluation; Exposure to; General Population; Genetic; Goals; Growth; Gynecology; Health; Helping to End Addiction Long-term; Home; Individual; Individual Differences; Infant; Infant Development; International; Longitudinal Studies; Longitudinal cohort study; Marijuana; Maternal Health; Maternal and Child Health; Maternal-fetal medicine; Medicaid; Metabolic; Minority Groups; Mothers; Multicenter Neonatal Research Network; Multicenter Studies; National Institute of Child Health and Human Development; Neighborhood Health Center; Neurodevelopmental Disability; Neurosecretory Systems; Nicotine; Normal Range; Opioid; Outcome; Parent-Child Relations; Participant; Perinatal; Population; Population Heterogeneity; Pregnancy; Pregnancy Trimesters; Pregnant Women; Prenatal care; Protocols documentation; Provider; Recording of previous events; Research; Resources; Rivers; Rural; Rural Community; Rural Health; Rural Minority; Rural Population; SARS-CoV-2 exposure; Sampling; Scientist; Second Pregnancy Trimester; Site; Social Behavior; Stress; Structure; Tobacco; Toxic Environmental Substances; Translational Research; Ultrasonography; United States National Institutes of Health; Universities; Weaning; Well in self; Woman; addiction; antenatal; autism spectrum disorder; behavioral health; biobank; biological systems; clinical research site; cohort; design; early experience; early life exposure; emotional behavior; experience; follow-up; high risk; illicit opioid; immune function; in utero; indexing; multimodal data; neonatal exposure; neurodevelopment; neuroimaging; opioid exposure; prenatal; prenatal exposure; prescription opioid; programs; prospective; recruit; research study; response; sample collection; socioeconomics; substance use; treatment program

Brain development during the early years goes through rapid change with vulnerable periods where a variety of environmental exposures can have a large and enduring impact in early neurodevelopment and long-term health outcomes. Experiences will permanently modify brain structure and function through epigenetic changes that contribute to individual differences, in addition to reciprocal interactions among brain plasticity and autonomic neuroendocrine, metabolic, and immune functions. Few studies have addressed how early brain development and trajectories are impacted by early experiences and potential biological interactions within a diverse population inclusive of rural and minority populations. The central goal of the HEAL Initiative: HEALthy Brain and Child Development study is to prospectively examine brain and behavioral development from birth through childhood with emphasis on the impact of in utero substance exposure on outcome. At the University of Alabama at Birmingham (UAB) and the University of Alabama (UA) we will enroll pregnant women during their second trimester and follow their infants with a comprehensive multimodal data longitudinal study. Strengths to UAB include the Comprehensive Addiction in Pregnancy Program (CAPP) that provides prenatal care and support to pregnant women with history of substance use. UAB OB supports several prenatal clinics within Jefferson and Blount County Departments of Health, neighborhood health centers, and the Complications clinic. UAB is actively enrolling participants for the HEAL Outcomes of Babies with Opioid exposure and the ACT NOW Weaning study. UAB is a site for the NICHD Maternal Fetal Medicine Network and the NICHD Neonatal Research Network for >25 years, with long-standing, well-established and highly productive collaborations with other centers. UA operates at the University Medical Center in Tuscaloosa that serves the majority of the Medicaid recipients in the region as well as rural clinics in surrounding counties, including those in the Alabama Black Belt. The UA team has expertise in neuroimaging, EEG, rural health, maternal health and child development. Therefore, there is demonstrated adequacy of clinical, research, administrative and facilities to accomplish this project. We clearly express our intent to participate in a cooperative manner with the other research sites, the HDCC, HCAC, the NIH Program Scientist and the NIH Program Official in all aspects of research in a manner consistent with the terms of the award. Specific Aims: 1. Determine typical neurodevelopmental trajectories and typical range of variability of brain development from birth through childhood in a diverse population. 2. Determine how early life exposure to opioids, other substances, and other adverse environmental circumstances affect these trajectories. 3. Determine how genetic influences interact with environmental factors to influence neurodevelopment. Design: 300 mother/child dyads (100 with and 200 without history of drug exposure) with complete longitudinal brain, behavioral and biological assessment in conjunction with other research sites within the HEAL Initiative.

早期的大脑发育经历了脆弱时期的快速变化 环境暴露可能会对早期神经发育产生巨大的影响 健康结果。经验将通过表观遗传变化永久修改大脑结构和功能 除了大脑可塑性之间的相互互动和 自主神经内分泌，代谢和免疫功能。很少有研究解决了大脑的早期 发展和轨迹受到早期经验和潜在的生物学相互作用的影响 包括农村和少数民族人口的多样化人口。 Heal倡议的核心目标：健康 大脑和儿童发展研究是为了前瞻性检查大脑和行为发展 在童年时期，重点是子宫内物质暴露对预后的影响。 在阿拉巴马大学伯明翰大学（UAB）和阿拉巴马大学（UA），我们将入学 妇女在妊娠中期，并以全面的多模式数据跟随婴儿 学习。 UAB的优势包括提供的全面成瘾计划（CAPP） 具有药物使用史的孕妇的产前护理和支持。 UAB OB支持几个产前 杰斐逊和布朗特县卫生部门，邻里卫生中心和诊所内 并发症诊所。 UAB正在积极招募参与者参加阿片类药物的婴儿的治疗结果 暴露与现在的断奶研究。 UAB是NICHD孕妇胎儿医学网络和 NICHD新生儿研究网络已有25年的历史 与其他中心的合作。 UA在Tuscaloosa的大学医学中心运营，该中心为 该地区的大多数医疗补助接收者以及周围县的农村诊所，包括 在阿拉巴马州黑带。 UA团队在神经影像，脑电图，农村健康，孕产妇健康方面具有专业知识 儿童发展。因此，临床，研究，行政和设施有足够的表现 完成这个项目。我们清楚地表达了与对方以合作方式参与的意图 研究网站，HDCC，HCAC，NIH计划科学家和NIH计划的官员 以符合奖励条款一致的方式进行研究。 具体目的：1。确定典型的神经发育轨迹和大脑的典型变异范围 从出生到童年的发展。 2.确定生命的早期暴露 阿片类药物，其他物质和其他不利的环境环境会影响这些轨迹。 3。 确定遗传影响如何与环境因素相互作用以影响神经发育。 设计：完整的纵向 大脑，行为和生物学评估与HEAS计划中的其他研究地点结合使用。