OUTCOME OF PRETERM SMALL FOR GESTATIONAL AGE ADOLESCENTS

候选人是一名儿科医生，拥有妇幼保健硕士学位。她是诊所的主治医生，负责高危儿童和儿童发展的后续工作。她已经开始了科学工作，并建立了与她的特殊兴趣有关的关系，了解怀孕相关和围产期事件对儿童生长和发育的长期结果的影响。她的近期目标是通过增加她对高危儿童和青少年神经发育评估的知识，并通过获得更多的大型数据库和生长曲线分析的统计分析培训，制定一个系统的低出生体重儿长期结局研究计划。这些知识将帮助她发展设计和进行多中心临床试验的能力，管理大型数据库，并设计有用的研究结果测量方法，以评估大规模人群的发展结果。她介绍了教学课程和具体的咨询，以实现这一知识。在UAB现有的多学科基础设施内，她将特别与Civitan国际研究中心合作，该中心专门从事儿童的发展和结果评估。她将与她的研究领域的几位资深教师专家合作。拟议的项目是一项前瞻性纵向研究，将评估参与连续小胎龄（SGA）研究的早产儿的长期结局，该研究是NICHD赞助的研究，招募了来自一个县的多产低收入孕妇，这些孕妇有宫内生长迟缓（IUGR）的风险。这些妇女和她们的婴儿在出生前、出生时、1岁和5岁时接受随访。这项拟议研究的总体假设是，早产SGA青少年的生长和发育与早产适合胎龄（阿加）儿童相比将受到损害。研究对象为1986 ~ 1988年出生的99例小于37孕周的SGA早产儿和121例小于37孕周的阿加早产儿。这些儿童在接受评估时将为11至13岁。将使用人体测量指标评估所有受试者的生长、骨骼质量发育、身体组成（双能X射线吸收测定法和骨龄）和性成熟。发展性评估将包括评估学业成绩、认知分数、学习障碍评估、行为和功能结果工具。本研究为了解IUGR后出生儿童的长期预后及其与产前和围产期事件的关系提供了重要信息。

The candidate is a Pediatrician with an MPH in maternal and child health. She is an attending physician in clinics for follow-up of high-risk children and child development. She has begun scientific work and established relationships related to her special interests on understanding the impact of pregnancy-related and perinatal events on the long-term outcome for child growth and development. Her immediate goals are to develop a systematic program of research on the long-term outcomes of low birth weight infants, by increasing her knowledge of assessments of neurodevelopment of children and adolescents at risk, and by obtaining more training in statistical analysis of large databases and growth curve analysis. This knowledge will assist her to develop her ability to design and conduct multi-center clinical trials, to manage large databases and to design useful research outcome measurements for evaluating developmental outcomes in large populations. She describes a didactic curriculum and specific consultations to achieve this knowledge. Within the multidisciplinary infrastructure, existing at UAB she will work in particular with the Civitan International Research Center, a center specialized in development and outcome assessments of children. She will be working with several senior faculty experts in her area of research. The proposed project is a prospective longitudinal study that will assess the long-term outcomes of preterm children who participated in the Successive Small for Gestational Age (SGA) Study, an NICHD sponsored study, that recruited multiparous low-income pregnant women at risk for Intrauterine Growth Retardation (IUGR) from a single county. These women and their infants were followed antenatally, at birth and at 1 and 5 years of age. The overall hypothesis of this proposed study is that growth and development of preterm SGA adolescents will be impaired compared to preterm Appropriate for Gestational Age (AGA) children. Growth and developmental outcomes will correlate with prenatal and perinatal variables after controlling for postnatal variables.The study will include 99 preterm (<37 weeks gestation) SGA and 121 preterm AGA children who were born between 1986 and 1988. These children will be 11 to 13 years at the time of the assessments. All participants will be assessed for growth using anthropometric measures, development of skeletal mass, body composition (dual energy X-Ray absorptiometry and bone age), and sexual maturation. Developmental assessment will include assessing academic achievement, cognitive scores, assessment of learning disabilities, behavioral and functional outcome instruments. This study should provide important information to understand the longterm outcomes for children who were born after IUGR and its relationship with prenatal and perinatal events.