SLEEP AND CHRONOBIOLOGY OF LATE-LIFE DEPRESSION

本申请提出Martin P. Szuba，M.D.对于指导临床 宾夕法尼亚大学科学家发展奖。 目标 该计划包括：1）支持他的发展成为一个 独立研究科学家2）支持和提高申请人的 作为睡眠和时间生物学的研究者， 老年人; 3）培养他在情绪方面的教师领导作用 宾夕法尼亚大学的疾病;以及4）加强对晚年情绪的研究 使用时间生物学的方法。 这些目标将围绕一个由四部分组成的计划：1） 正式的学术课程和辅导，旨在提高他的研究 skills. 2)研究培训，由大卫丁格斯和伊拉博士监督 卡茨 该培训将包括在监督下参加三个 睡眠和呼吸神经生物学中心正在进行的研究， 老年抑郁症临床研究中心（CRC）：医学- 精神科合并症（I. Katz，PI）。 3)执行单独的 研究项目：第一个系统的随机，双盲， 外源性褪黑激素作用的安慰剂对照治疗试验 抑郁症患者的睡眠、情绪和昼夜节律 老年受试者 该研究的具体目标包括彻底的 对老年抑郁症失眠患者的主观评价， 睡眠的行为和生理指标，在实验室和 在家里，以及记录昼夜生理过程中， 揭盲方案（常规），治疗前后 褪黑素或安慰剂4）作为主要研究者， 一份独立的研究资助申请

This application proposes Martin P. Szuba, M.D. for a Mentored Clinical Scientist Development Award at the University of Pennsylvania. The aims of this program include: 1) to support his development into an independent research scientist 2) to support and enhance the applicant's development as an investigator in sleep and chronobiology in the elderly; 3) to develop him for a faculty leadership role in mood disorders at Penn; and 4) to enhance the study of late-life mood disorders at Penn, using a chronobiologic approach. These aims will be structured around a four-part plan: 1) A program of formal academic courses and tutorials aimed at enhancing his research skills. 2) Research training, supervised by Drs. David Dinges and Ira Katz. This training will include supervised participation in three ongoing studies of the Center for Sleep and Respiratory Neurobiology and the Clinical Research Center (CRC) in Depression in the Aged: Medical- Psychiatric Co-Morbidity (I. Katz, PI). 3) Performance of a separate research project: The first systematic randomized, double-blind, placebo-controlled treatment trial of the effects of exogenous melatonin administration on sleep, mood, and circadian rhythms in depressed elderly subjects. The specific aims of the study include a thorough evaluation in elderly depressed subjects with insomnia of subjective, behavioral, and physiological indices of sleep, in the laboratory and at home, as well as recording of circadian physiology during an unmasking protocol (constant routine), prior to and following treatment with melatonin or placebo. 4)Preparation, as Principal Investigator, of an independent research grant application.