SLEEP AND CHRONOBIOLOGY OF LATE-LIFE DEPRESSION

此应用程序推荐Martin P.Szuba医学博士作为临床导师 宾夕法尼亚大学科学家发展奖。目标 这一计划包括：1)支持他发展成为一名 独立研究科学家2)支持和加强申请人的 在睡眠和时间生物学方面发展成为一名研究员 老年人；3)培养他在情绪方面的教职员工领导角色 宾夕法尼亚大学的精神障碍；以及4)加强对晚年情绪的研究 宾夕法尼亚大学的疾病，使用时间生物学的方法。 这些目标将围绕四个部分的计划构建：1)计划 旨在加强他的研究的正式学术课程和教程 技能。2)研究培训，由David Dinges博士和Ira博士指导 卡茨。本次培训将包括三个项目的督导参与 睡眠和呼吸神经生物学中心正在进行的研究和 老年抑郁症的临床研究中心：医学- 精神疾病共病(I.Katz，Pi)。3)履行一项独立的 研究项目：首次系统随机、双盲、 外源性褪黑素作用的安慰剂对照治疗试验 药物对抑郁症患者睡眠、情绪和昼夜节律的影响 老年受试者。这项研究的具体目的包括 主观性失眠对老年抑郁症患者的评价 睡眠的行为和生理指标在实验室和 在家中，以及记录昼夜生理 治疗前后的揭秘方案(常量常规) 使用褪黑激素或安慰剂。4)作为首席调查员，准备 一份独立的研究资助申请。

This application proposes Martin P. Szuba, M.D. for a Mentored Clinical Scientist Development Award at the University of Pennsylvania. The aims of this program include: 1) to support his development into an independent research scientist 2) to support and enhance the applicant's development as an investigator in sleep and chronobiology in the elderly; 3) to develop him for a faculty leadership role in mood disorders at Penn; and 4) to enhance the study of late-life mood disorders at Penn, using a chronobiologic approach. These aims will be structured around a four-part plan: 1) A program of formal academic courses and tutorials aimed at enhancing his research skills. 2) Research training, supervised by Drs. David Dinges and Ira Katz. This training will include supervised participation in three ongoing studies of the Center for Sleep and Respiratory Neurobiology and the Clinical Research Center (CRC) in Depression in the Aged: Medical- Psychiatric Co-Morbidity (I. Katz, PI). 3) Performance of a separate research project: The first systematic randomized, double-blind, placebo-controlled treatment trial of the effects of exogenous melatonin administration on sleep, mood, and circadian rhythms in depressed elderly subjects. The specific aims of the study include a thorough evaluation in elderly depressed subjects with insomnia of subjective, behavioral, and physiological indices of sleep, in the laboratory and at home, as well as recording of circadian physiology during an unmasking protocol (constant routine), prior to and following treatment with melatonin or placebo. 4)Preparation, as Principal Investigator, of an independent research grant application.