PHONATION AND PHONATORY CONTROL IN VOCAL TREMORS

该项目的总体目标是描述和激励 在发声震颤中控制发声。 围绕这一问题的工作假设 该项目的组织者提出， 由于中枢之间的相互作用而调节声带振动 以及控制（或破坏控制） 语音和语音机制。该项目侧重于一个方面， 系统，声带振动和发声的控制， 外周（喉）水平。 要实现的具体目标 在这一时期，主要有以下几点：1）确定生理基础 对于喉生物力学在产生发声震颤中的作用， 测量喉肌活动、声门下压，以及 呼吸运动模式 2)研究外围设备的作用 声颤调制中的反射反馈回路 通过电刺激喉部肌肉的扰动。 第三章 用发声的计算机模型模拟声音震颤，使用a） 喉硬度和声门下的假设输入参数 压力，以及B）来自患者的相同生理输入参数 记录纳入模型，并比较模拟 患者数据。 这项培训补助金的重点是获得技能和经验， 喉部建模和发声仿真。培训将在 肌电信号分析，多通道记录， 语音研究仪器，统计和研究设计。 该项目还将大量面向计算机，并调查 喉区：相对未被探索的喉部模型区，发声区 病理条件下的控制。 理论研究将研究 喉硬度、声门下压力、相位和 肌肉激活，它们对调制的影响（幅度和频率） 声带振荡，并开发反馈回路来模拟 假设的外围振荡器。 实验阶段包括 对喉部神经肌肉和呼吸输入的研究。 这 关于声音震颤的信息将应用于模型模拟， 使用生理信号作为输入模型参数。

The overall goal of this project is to characterize and stimulate the control of phonation in vocal tremor. The working hypothesis around which the project is organized proposes the vocal tremor results from modulation of vocal fold vibration due to an interaction between central and peripheral oscillators that control (or undermine control of) the voice and speech mechanism. This project focuses on one aspect of the system, vocal fold vibration and the control of voice production at a peripheral (laryngeal) level. The specific aims to be accomplished during this period are as follows: 1) Determine the physiological basis for laryngeal biomechanics in production of vocal tremor through measurement of laryngeal muscle activity, subglottal pressure, and respiratory movement patterns. 2) Investigate the role of peripheral reflex feedback loops in vocal tremor modulation through system perturbation via electrical stimulation of laryngeal muscles. 3) Simulate vocal tremor with computer models of phonation, using a) hypothetical input parameters for laryngeal stiffness and subglottal pressure, and b) the same physiological input parameters from patient recordings incorporated into the models, and comparison of simulations with patient data. This training grant focuses on acquisition of skills and experience in laryngeal modeling and phonation simulation. Training will be gained in electromyographic signal analysis, multi-channel recording and instrumentation for speech research, and statistics and research design. The project will also be heavily computer-oriented and investigate an area of laryngeal modeling that is relatively unexplored, phonatory control under pathological conditions. Theoretical studies will examine modulations in laryngeal stiffness, subglottal pressure, phase, and muscle activation, their effects on modulation (amplitude and frequency) of vocal fold oscillation, and develop feedback loops to simulate hypothesized peripheral oscillators. The experimental phase consists of studies of neuromuscular and respiratory input to the larynx. This information about vocal tremor will be applied to model simulations with the use of physiological signals as input model parameters.