Electrode Array Reanimation of the Paralyzed Larynx

电极阵列使瘫痪的喉部复活

• 批准号: 7027640
• 负责人: MARSHALL E SMITH
• 金额: $ 18.25万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-05 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7027640
• 关键词: cats; electrodes; electromyography; implant; laryngeal nerves; laryngoscopy; larynx disorder; medical implant science; speech; technology /technique development; vocal cords

DESCRIPTION (provided by applicant): The overall goal of this project is to establish a reliable means of reanimation of the paralyzed larynx in an animal model. The eventual direction of this research is to develop a device for human implantation to restore laryngeal function after vocal fold paralysis. The hypothesis driving this project is that an implanted electrode array in the peripheral recurrent laryngeal nerve (RLN) can selectively stimulate laryngeal adductor muscles and abductor muscles. This principle can then be used to design a device that will reanimate a paralyzed vocal fold and restore laryngeal functions of phonation and respiration. Thus, the major outcome variable is to restore physiologic adductor and abductor vocal fold movement. In work toward these goals, a well-established cat model of laryngeal paralysis is used to explore the potential applications of this device. The specific aims of this proposal include: 1) Determine the topographic orientation of the nerve fibers in the RLN in the region where an electrode array can be implanted, 2) Determine the feasibility of selective reanimation of vocal fold movement in an animal vocal fold paralysis model by electrode array stimulation of the RLN in two surgical conditions of RLN-RLN neurorraphy, and ansa-RLN neurorraphy, and 3) Determine the long-term stability of electrode array implant in the RLN. To accomplish these aims, the surgical procedures will be performed in the animal model and electrode array implanted after the neurorraphy has healed. The electrode array is selectively stimulated, laryngoscopy and laryngeal EMG is performed to observe for vocal fold adductor and abductor movement and activation. The electrode array is secured and wired to an external pedestal mounted on the head. This allows serial electrode stimulation and observations of laryngeal movement over an extended length of time. Nerve samples will be harvested and studied to examine the effects of the implanted array on RLN fibers.

描述（由申请人提供）：本项目的总体目标是在动物模型中建立一种可靠的瘫痪喉复苏方法。本研究的最终方向是开发一种用于人体植入的装置，以恢复声带麻痹后的喉功能。驱动该项目的假设是，外周喉返神经（RLN）中的植入电极阵列可以选择性刺激喉内收肌和外展肌。这一原理可以用来设计一种装置，使瘫痪的声带恢复活力，恢复喉部的发声和呼吸功能。因此，主要的结果变量是恢复生理性内收肌和外展肌声带运动。在实现这些目标的工作中，一个完善的猫喉麻痹模型被用来探索这种设备的潜在应用。这项建议的具体目标包括：1）确定RLN中的神经纤维在电极阵列可以被植入的区域中的地形定向，2）确定在RLN-RLN神经吻合术和袢-RLN神经吻合术的两种手术条件下通过RLN的电极阵列刺激在动物声带麻痹模型中选择性地使声带运动复苏的可行性，以及3）确定电极阵列植入物在RLN中的长期稳定性。为了实现这些目标，将在动物模型中进行外科手术，并在神经损伤愈合后植入电极阵列。选择性刺激电极阵列，喉镜下观察声带内收肌和外展肌的运动和激活情况。电极阵列被固定并连接到安装在头部上的外部基座。这允许在延长的时间长度上连续电极刺激和观察喉部运动。将采集神经样本并进行研究，以检查植入阵列对RLN纤维的影响。