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RNA/PROTEIN INTERACTIONS REGULATING MRNA STABILITY

RNA/PROTEIN INTERACTIONS REGULATING MRNA STABILITY
RNA/蛋白质相互作用调节 mRNA 稳定性
批准号:
2701221
负责人:
MEGERDITCH KILEDJIAN
金额:
$14.84万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-05-01 至 2002-04-30

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DESCRIPTION (Adapted from investigators's abstract) The overall objective of this proposal is to further the understanding of the determinants that regulate globin mRNA stability. This proposal has three main aims: 1) to identify all the alpha complex proteins both biochemically and genetically; 2) to functionally characterize the alpha-globin mRNA stability mechanisms by using an alpha-complex dependent in vitro mRNA decay system; and 3) to identify additional mRNA(s) bound by and possibly regulated by the alpha complex.
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