NEURAL PROCESSING OF COMMUNICATION SOUNDS

通讯声音的神经处理

• 批准号: 2674524
• 负责人: JAMES R KOZLOSKI
• 金额: $ 0.58万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2674524
• 关键词: Osteichthyes; acoustic nerve; afferent nerve; auditory nuclei; auditory pathways; hearing; medulla oblongata; neural information processing; sound frequency

The research proposed here is directed toward developing a better understanding of how critical features of communication signals are coded and processed by neural circuits in the brain. The specific goal is to elucidate neurobiological processes which are fundamental to natural auditory communication. Auditory nervous systems have the task of processing important timing cues in communication signals, whether in human speech or in the acoustic communication of a diverse array of other vertebrate animals. The basic organization of auditory pathways is similar across vertebrate classes, and certain species of vertebrate animals are particularly valuable for addressing issues relating to the neurobiology of hearing, communication, and the learning processes which they subsume. In particular, the neurophysiological studies proposed here address problems in fundamental neuroscience which are potentially relevant to import mental health issues, including the design of treatments for individuals with auditory-related learning dysfunctions. Recent studies suggest that poor discrimination of auditory time cues by language impaired children may lie at the root of a broad spectrum of learning disorders. The proposed research focuses on the neural processing of time features in the auditory system of a vertebrate animal which uses a limited set of simple sounds for courtship communication. By conducting neuroanatomical and neurophysiological experiments in the auditory brainstem of Pollimyrus (ie., auditory nerve to midbrain), the substrate and method for the coding of temporal features in sonic stimuli will be examined. New knowledge about how the normal vertebrate nervous system responds to these signals will contribute to the basic biomedical science needed to design informed treatments of dysfunction. The fish (Pollimyrus) is an excellent animal model for this research because: 1. Its repertoire of sounds has been carefully characterized, 2. The dominant features of its sounds are temporal patterns, and 3. Its ear appears to be adapted time analysis (the animal~s hearing is based on an array of hair cells like that found in the human ear, but it does not posses a mechanical frequency analyzer like in the mammalian cochlea). This animal has also proven to be outstanding for single neuron physiological studies and for anatomical studies of the auditory pathway. The proposed research combines neurophysiological studies of the auditory system with neuroanatomical pathway tracing from those auditory centers which have been characterized physiologically. Having made a careful choice of an appropriate animal model, I expect that progress will be made toward a better understanding of fundamental mechanisms of vertebrate communication.

这里提出的研究旨在开发一种更好的 了解通信信号的关键特征 由大脑中的神经回路编码和处理。 具体 目的是阐明神经生物学过程，这是基本的 自然的听觉交流。 听觉神经系统 在通信中处理重要的时间线索的任务 信号，无论是在人类的语言或在声学通信 其他脊椎动物的多样性。 基本 听觉通路的组织在脊椎动物中是相似的， 类，某些种类的脊椎动物特别是 对于解决与神经生物学相关的问题很有价值， 听力、沟通和学习过程， 顺从 特别是，这里提出的神经生理学研究解决了 基础神经科学中的问题， 引入心理健康问题，包括设计治疗方法， 与学习障碍有关的人。 最近 研究表明，听觉时间线索的区分能力差， 语言障碍儿童可能是一个广泛的根源， 学习障碍 拟议的研究重点是时间的神经处理 脊椎动物听觉系统的特征， 有限的一组简单的声音用于求偶交流。 通过 进行神经解剖学和神经生理学实验， Pollimyrus的听觉脑干（即，听神经 中脑）、用于编码颞叶神经元的基质和方法 将检查声音刺激的特征。 新认识 正常的脊椎动物神经系统如何对这些信号做出反应 将有助于设计所需的基础生物医学科学， 功能障碍的知情治疗。 鱼（Pollimyrus）是一种很好的动物模型 因为：1.它的所有声音都经过仔细的描述， 2.其语音的主要特征是时间模式，和3。 它的耳朵似乎适应了时间分析（动物的听力是 基于一系列类似于人耳的毛细胞， 它不像在机械频率分析仪 哺乳动物耳蜗）。 这种动物也被证明是杰出的单神经元 生理学研究和听觉的解剖学研究 通路 拟议的研究结合了神经生理学 听觉系统的神经解剖通路追踪研究 这些听觉中枢的特点是 生理上的。 在仔细选择了一个合适的 动物模型，我希望朝着更好的方向取得进展 了解脊椎动物的基本机制 通信

项目成果

Temporal encoding for auditory computation: physiology of primary afferent neurons in sound-producing fish.

听觉计算的时间编码：发声鱼初级传入神经元的生理学。

• DOI: 10.1523/jneurosci.22-14-06290.2002
• 发表时间: 2002
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Suzuki,Aae;Kozloski,James;Crawford,JohnD
• 通讯作者: Crawford,JohnD

Functional neuroanatomy of auditory pathways in the sound-producing fish Pollimyrus.

发声鱼Pollimyrus听觉通路的功能神经解剖学。

• 发表时间: 1998
• 期刊: The Journal of comparative neurology.
• 作者: Kozloski,J;Crawford,JD
• 通讯作者: Crawford,JD