Further Development and Innervation of a 96 Well, 3D, Skin Model for Drug and Toxicity Testing

阿尔赛组学公司开发了独特的非动物、非人造人类皮肤移植分析方法(Skimune和Skimune3D)，可以测试包括化妆品在内的新药和化合物的安全性和有效性。Skimune和Skimune 3D是通过使用人类皮肤、组织和血液开发出来的，因此给予了人类对化合物的反应，而不是目前使用的动物模型。Alcytics的创新分析通过早期评估其安全性，使制药、化学和化妆品行业的产品能够更快地进入临床和/或市场。Alcytics最近在Innovate UK的资助下，以96孔的格式开发了Skimune3D，从而改善了他们的服务提供。96孔格式允许高通量筛查，节省了客户的金钱和时间，并且Skimune3D能够在临床试验之前进行多次剂量测试和患者药物剂量的信息。在这个当前的项目中，我们的目标是通过生物打印Skimune3D进一步利用这一模型，并验证生物打印的模型用于安全测试，从而创建更标准化的服务提供。Alcyome还将与Axol有限公司合作将神经细胞纳入模型，以实现神经毒性的安全测试。总之，该项目将增加Alcytics的服务提供，并进入新的全球市场和产品开发。

Alcyomics has developed unique non-animal non-artificial human skin explant assays (Skimune & Skimune3D) which can test for safety and efficacy of novel drugs and compounds including cosmetics. Skimune and Skimune 3D have been developed by using human skin, tissue and blood therefore giving a human response to the compounds rather than, the currently used, animal models.Alcyomics innovative assays enable the products of the pharmaceutical, chemical and cosmetic industries to reach the clinic and/or the market place quicker by early assessment of their safety profiles.Alcyomics has recently improved their service offering by the aid of Innovate UK funding by developing Skimune3D in a 96 well format. The 96 well format allows for high throughput screening saving clients both money and time and Skimune3D enables multiple dose testing and information on patient drug dosage prior to clinical trial.In this current project we aim to further exploit this model by bioprinting Skimune3D and validate the bioprinted model for safety testing, therefore creating a more standardised service offering.Alcyomics will also work with Axol Ltd to incorporate nerve cells into the model in order to enable safety testing for neural toxicity.In summary this project will increase Alcyomics' service offering and in roads into new global markets and product development.