NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
基本信息
- 批准号:6271494
- 负责人:
- 金额:$ 6.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-08-01 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:3,4 dihydroxyphenylacetate association learning avoidance behavior behavior test behavioral /social science research tag behavioral habituation /sensitization cocaine cognition disorders developmental neurobiology dopamine drug abuse embryo /fetus toxicology gender difference laboratory rat longitudinal animal study mood disorders motivation neuromuscular function nicotine prenatal stress statistics /biometry tobacco abuse
项目摘要
Multiple drug use among female cocaine abusers is common during pregnancy.
Estimates are that 85% of pregnant cocaine users also smoke cigarettes;
while use of alcohol, marijuana, amphetamine an tranquilizers decreases
between the first and third trimesters, tobacco use does not. Despite the
frequency of their combined use, there has been no systematic study of the
effects of prenatal cocaine and nicotine exposure. However, use of either
drug alone during pregnancy is linked with pregnancy complications,
impaired growth and subtle behavioral abnormalities, maternal smoking is
also a marker variable for long-term intellectual impairment.
The proposed research will determine the behavioral sequelae of prenatal
exposure to cocaine and nicotine, either alone or in combination, in
offspring using a rat model developed in our laboratory. The working
hypothesis is that exposure of the developing brain to non-teratogenic
doses of these drugs will disrupt the structural and functional
organization of the CNS, which in turn will alter behavior in the
offspring. The model involves the daily subcutaneous administration of 20
mg/kg of cocaine and/or 5 mg/kg of nicotine by osmotic pump on gestation
days (GD) 8 through 21. Both pair-fed and saline-treated dams will serve
as controls. Plasma levels of cocaine, nicotine and their major
metabolites will be determine in dams on GD 15 and mothers and pups at
birth; dopamine and DOPAC levels will be assayed in several brain region
in offspring at various ages. Using a split-litter design, males and
females from the 5 prenatal treatment conditions will be tested in a
variety of behavioral paradigms. A longitudinal (from 1 week to 15 months
of age] approach will be used to: 1) identify the behavioral domains
(cognitive, emotional/motivational and motor) affected by prenatal cocaine
and nicotine exposure; 2) determine whether combined drug exposure
exacerbates or ameliorates the behavioral effects of either drug alone; 3)
investigate whether these changes represent a delay in the rat of
development, a later appearing alteration in functional capacity of the
adult, or an induction of premature senescence; and 4) assess the
possibility of gender-specific effects.
These experiments will provide some of the first longitudinal data on the
effects of prenatal exposure to cocaine and/or nicotine on both male and
female offspring, and should begin to establish a consensus about the
nature of the behavioral abnormalities produce by gestational exposure to
these two drugs. The use of a large battery of behavioral tests, and the
choice of the prenatal exposure window and drug doses most frequently used
will allow for the replication and extension of the work of several
laboratories and facilitate the resolution of conflicting findings
regarding the effects of prenatal exposure to either drug alone. As the
behaviors targeted also reflect cognitive and/or performance deficits
reported in the clinical literature, the outcome of this research may
serve as a guideline for determining the relative risks of combined use of
these two drugs during pregnancy to the offspring. The identification of
deficits as transient of long-term and the domains affected may impact the
choice of treatment options.
女性可卡因滥用者在怀孕期间使用多种药物很常见。
据估计,85%的孕妇可卡因使用者也吸烟;
而酒精、大麻、安非他明和镇静剂的使用减少了,
在怀孕的第一个和第三个三个月之间,烟草的使用则不会。尽管
他们联合使用的频率,一直没有系统的研究,
产前可卡因和尼古丁暴露的影响。然而,使用
怀孕期间单独使用药物与妊娠并发症有关,
发育不良和微妙的行为异常,母亲吸烟是
也是长期智力障碍的标志变量。
这项拟议中的研究将确定产前行为后遗症
暴露于可卡因和尼古丁,无论是单独或组合,
使用我们实验室开发的大鼠模型。工作
假设是发育中大脑暴露于非致畸的
这些药物的剂量将破坏结构和功能,
中枢神经系统的组织,这反过来又会改变行为,
后代该模型涉及每日皮下施用20
妊娠期通过渗透泵给予可卡因和/或尼古丁5 mg/kg
第8 - 21天(GD)。成对喂养和盐水处理的母鼠都将
作为对照可卡因、尼古丁及其主要成分的血浆水平
将在GD 15测定母体代谢物,并在
分娩;将在几个脑区测定多巴胺和DOPAC水平
在不同年龄的后代中。采用分窝设计,
来自5种产前治疗条件的女性将在
各种行为模式。纵向(1周至15个月)
方法将用于:1)确定行为域
(认知、情感/动机和运动)受产前可卡因影响
和尼古丁暴露; 2)确定是否联合药物暴露
加重或改善任一单独药物的行为效应; 3)
调查这些变化是否代表大鼠的延迟,
发展,后来出现的功能能力的改变,
成人,或诱导过早衰老;和4)评估
性别差异的可能性。
这些实验将提供一些关于地球的第一批纵向数据。
产前暴露于可卡因和/或尼古丁对男性和
女性后代,并应开始建立一个共识,
由于妊娠期暴露于
这两种药物。使用大量的行为测试,
产前暴露窗口的选择和最常用的药物剂量
将允许复制和扩展几个
实验室和促进解决矛盾的结果
关于产前单独接触任何一种药物的影响。为
目标行为也反映了认知和/或表现缺陷
在临床文献中报告,本研究的结果可能
作为确定联合使用的相对风险的指南
这两种药物在怀孕期间对后代的影响。的识别
短期或长期的赤字和受影响的领域可能会影响
选择治疗方案。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sonya K Sobrian其他文献
Sonya K Sobrian的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sonya K Sobrian', 18)}}的其他基金
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6453036 - 财政年份:2001
- 资助金额:
$ 6.35万 - 项目类别:
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6494799 - 财政年份:2001
- 资助金额:
$ 6.35万 - 项目类别:
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6434942 - 财政年份:2001
- 资助金额:
$ 6.35万 - 项目类别:
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6344847 - 财政年份:2000
- 资助金额:
$ 6.35万 - 项目类别:
PRENATAL ALCOHOL--EFFECTS ON CENTRAL DOPAMINE RECEPTOR SUBTYPES
产前酒精——对中枢多巴胺受体亚型的影响
- 批准号:
6347172 - 财政年份:2000
- 资助金额:
$ 6.35万 - 项目类别:
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6352954 - 财政年份:2000
- 资助金额:
$ 6.35万 - 项目类别:
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6219048 - 财政年份:1999
- 资助金额:
$ 6.35万 - 项目类别:
PRENATAL ALCOHOL--EFFECTS ON CENTRAL DOPAMINE RECEPTOR SUBTYPES
产前酒精——对中枢多巴胺受体亚型的影响
- 批准号:
6200931 - 财政年份:1999
- 资助金额:
$ 6.35万 - 项目类别:
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6316644 - 财政年份:1999
- 资助金额:
$ 6.35万 - 项目类别:
NEUROBEHAVIORAL EFFECTS OF PRENATAL COCAINE AND NICOTINE EXPOSURE
产前接触可卡因和尼古丁对神经行为的影响
- 批准号:
6107031 - 财政年份:1998
- 资助金额:
$ 6.35万 - 项目类别:
相似海外基金
Neural circuit mechanisms for temporal association learning
时间关联学习的神经回路机制
- 批准号:
10531595 - 财政年份:2020
- 资助金额:
$ 6.35万 - 项目类别:
Neural circuit mechanisms for temporal association learning
时间关联学习的神经回路机制
- 批准号:
10300428 - 财政年份:2020
- 资助金额:
$ 6.35万 - 项目类别:
Neuronal correlates of association learning and memory in the carrion crow
食腐乌鸦关联学习和记忆的神经相关性
- 批准号:
273724012 - 财政年份:2015
- 资助金额:
$ 6.35万 - 项目类别:
Research Grants
Interaction between prefrontal cortex and mesofrontal dopamine during cue-reward association learning
提示奖励关联学习期间前额皮质和中额叶多巴胺之间的相互作用
- 批准号:
25890024 - 财政年份:2013
- 资助金额:
$ 6.35万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Neuronal mechanisms for the odor-food association learning and memory consolidation during postprandial sleep
餐后睡眠期间气味-食物关联学习和记忆巩固的神经机制
- 批准号:
23240046 - 财政年份:2011
- 资助金额:
$ 6.35万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Time and Contingency in Association Learning
联想学习的时间和偶然性
- 批准号:
7823616 - 财政年份:1979
- 资助金额:
$ 6.35万 - 项目类别:
Continuing Grant
Time and Contingency in Association Learning
联想学习的时间和偶然性
- 批准号:
7601229 - 财政年份:1976
- 资助金额:
$ 6.35万 - 项目类别:
Continuing grant
Temporary stimulus-response binding as a mechanism in incidental association learning II
临时刺激-反应结合作为偶然联想学习的机制 II
- 批准号:
269503548 - 财政年份:
- 资助金额:
$ 6.35万 - 项目类别:
Research Grants