CURRENT DENSITY ELECTROENCEPHALOGRAPY

癫痫等神经系统疾病的诊断可能很快就会 通过密集传感器阵列的技术进步得到改进 脑磁图（MEG）和脑电图（EEG）。脑电图是 对公共卫生政策特别重要，因为它 比MEG或任何血液动力学（MRI， PET、SPECT）成像模式。 临床广泛应用致密 传感器阵列EEG对神经系统疾病的诊断可能是 不仅通过对源定位的推断， 最大限度地提高临床脑电图仪的解释技能 通过提供高分辨率波形和地形图， 数据 通过适当的空间采样和基于3D样条插值的 在真实的头部几何形状上，头皮电势的拉普拉斯算子 表征了大脑电场的颅骨电流密度。 拟议的第二阶段研究实施了PI的创新， 具有头皮EEG的足够空间采样的电流密度EEG EGI的128通道测地线传感器网络 随着这一进步 实现，电流密度EEG将成为一个有用辅助， 常规EEG和偶极子建模在临床诊断和 神经系统疾病的管理。 建议的商业应用 传统EEG的空间采样不足正变得越来越重要。 越来越清晰。 密集阵列脑电图，加上增强的空间 电流密度测量提供的详细信息，可能会成为强大的新 临床脑电图学家手中的工具。

Diagnosis of neurological disorders such as epilepsy may soon be improved by the technical advances in dense sensor array magnetoencephalography (MEG) and electroencephalography (EEG). EEG is particularly important to public health policy because it is less expensive (by factor of 10 to 100) than MEG or any hemodynamic (MRI, PET, SPECT) imaging modality. Widespread clinical application of dense sensor array EEG to the diagnosis of neurological disorders may be achieved not only through inferences on source localization, but through maximizing the clinical electroencephalographer's interpretive skills with surface EEG by providing high-resolution waveform and topographic data. With adequate spatial sampling and 3D spline interpolations based on realistic head geometry, the Laplacian of the scalp potential characterized the skull current density of the brain's electrical field. The proposed Phase II research implements the PI's innovations in current density EEG with an adequate spatial sampling of the scalp EEG with EGI's 128-channel Geodesic Sensor Net. With this advance implementation, current density EEG will be come a useful adjunct to conventional EEG and to dipole modeling in the clinical diagnosis and management of neurological disorders. PROPOSED COMMERCIAL APPLICATION The inadequate spatial sampling of conventional EEG is becoming increasing clear. Dense array EEG, coupled with the enhanced spatial detail provided by current density measure, may become powerful new tools in the hands of clinical electroencephalographers.