NEW METHODS TO IMPROVE SPATIAL RESOLUTION OF EEG

拟议的工作涉及对标准方法和 基于物理集成的脑电新方法的发展， 具有既定脑电研究的工程和计算机方法。这个 主要目标是提高脑电的空间分辨率，以便 头皮记录更准确地反映了潜在的 神经来源。因此，参比电极上的活动的影响 和体积传导通过以下步骤从未处理的EGG信号中去除 新的电流源密度和空间反褶积方法的手段 将在理论上和通过头骨坦克和人类来开发 受试者实验。我们方法的独特之处包括试验性 估计局部头骨阻力函数，使用逼真 人头的有限元模型，颅骨坦克数据的集成 以及从慢性深度电极患者那里获得的数据 四种方法的理论发展和评价 来源：本地化与静态、本地化与非静态、 分布式和静态、分布式和非静态。因此， 所提出的方法适用于各种自发性的研究。 脑电、脑干诱发电位和事件相关电位。

The proposed work is concerned with evaluation of standard methods and the development of new methods in EEG based on the integration of physics, engineering and computer methods with established EEG research. The principal objective is to improve the spatial resolution of EEG so that scalp recordings more accurately represent the activity of the underlying neural sources. Thus, the effects of activity at the reference electrode and volume conduction are to be removed from unprocessed EGG signals by means of new current source density and spatial deconvolution methods which are to be developed both theoretically and by means of skull tank and human subject experiments. Unique features of our approach include experimental estimates of the local skull resistance function, the use of a realistic finite element model of the human head, the integration of skull tank data and data obtained from patients with chronic depth electrodes with the theoretical development, and evaluation of all methods for four kinds of sources: localized and stationary, localized and nonstationary, distributed and stationary, distributed and nonstationary. Thus, the proposed methods are applicable to a wide variety of studies of spontaneous EEG, brainstem evoked potentials, and event related potentials.