NEW METHODS TO IMPROVE SPATIAL RESOLUTION OF EEG

拟议的工作涉及标准方法的评价和 发展新的方法在脑电图的基础上整合物理， 工程和计算机方法与既定的脑电图研究。 的 主要目的是提高EEG的空间分辨率， 头皮记录更准确地反映了潜在的活动， 神经源 因此，在参比电极处的活性的影响 和容积传导从未处理的EGG信号中去除， 新的电流源密度和空间反褶积方法， 在理论上和通过头骨罐和人类的方式来开发 主题实验 我们的方法的独特之处包括实验性的 估计的局部颅骨阻力函数，使用一个现实的 人体头部的有限元模型，颅骨槽数据的集成 以及从具有慢性深部电极的患者获得的数据， 理论的发展，并评价所有方法的四种 源：局部的和固定的，局部的和非固定的， 分布的和固定的，分布的和非固定的。 因此 所提出的方法适用于各种各样的自发性 EEG、脑干诱发电位和事件相关电位。

The proposed work is concerned with evaluation of standard methods and the development of new methods in EEG based on the integration of physics, engineering and computer methods with established EEG research. The principal objective is to improve the spatial resolution of EEG so that scalp recordings more accurately represent the activity of the underlying neural sources. Thus, the effects of activity at the reference electrode and volume conduction are to be removed from unprocessed EGG signals by means of new current source density and spatial deconvolution methods which are to be developed both theoretically and by means of skull tank and human subject experiments. Unique features of our approach include experimental estimates of the local skull resistance function, the use of a realistic finite element model of the human head, the integration of skull tank data and data obtained from patients with chronic depth electrodes with the theoretical development, and evaluation of all methods for four kinds of sources: localized and stationary, localized and nonstationary, distributed and stationary, distributed and nonstationary. Thus, the proposed methods are applicable to a wide variety of studies of spontaneous EEG, brainstem evoked potentials, and event related potentials.