PHYSICAL AND DIGITAL PHANTOMS OF HUMAN HEAD

人体头部的物理和数字幻像

• 批准号: 2034278
• 负责人: PAUL L NUNEZ
• 金额: $ 29.49万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2034278
• 关键词: artificial intelligence; biological models; brain electrical activity; computational neuroscience; digital imaging; electrical conductance; electrical property; electrodes; electroencephalography; evoked potentials; head; human data; neuroanatomy; phantom model; plastics

We propose to develop accurate models of the electrical properties of the human head. The Physical Head Model will be constructed with layers of conductive plastics varying in electrical resistivity. Imbedded current sources will be driven through a computer interface. The source waveforms will include representations of actual EEG data corresponding to different physiological states, computed waveforms will include representations of actual EEG data corresponding to different physiological states, computed waveforms with known statistical variation in both time and space, and waveforms generated by mathematical models of neocortical dynamic function. The Digital Head Model will simulate the physical model, and it will allow exploration of a variety of source geometries and head tissue conductivities. The Digital Head Model will include anatomical registration procedures to facilitate forward modeling with neuroimaging data such as from the BrainMap database. The Head Models will provide critical tests of the validity of present and future source localization methods. These Models will form a basis for interactive training programs in human brain electrophysiology for both research and clinical settings. PROPOSED COMMERCIAL APPLICATION: In addition to use in research laboratories, the simulations will support training curricular for neurology residence programs., cognitive neuroscience graduate programs, and neuroscience undergraduate courses.

我们建议开发精确的模型的电性能的 人头 物理头部模型将由多层 电阻率变化的导电塑料。 嵌入电流 源将通过计算机接口驱动。 震源波形 将包括对应于不同的EEG的实际EEG数据的表示 在生理状态下，计算的波形将包括 对应于不同生理状态的实际EEG数据，计算 在时间和空间上具有已知统计变化的波形，以及 新皮层动态数学模型产生的波形 功能 数字头部模型将模拟物理模型， 将允许探索各种源几何形状和头部组织 电导率 数字头部模型将包括解剖结构 配准程序，以促进神经成像的前向建模 例如BrainMap数据库。 头部模型将提供 对当前和未来震源定位的有效性进行严格检验 方法. 这些模型将构成互动培训计划的基础 用于研究和临床环境的人脑电生理学。 建议的商业应用：除了用于研究 实验室，模拟将支持培训课程， 神经病学住院计划，认知神经科学研究生课程， 和神经科学本科课程。