MECHANISM OF TIAR REPRESSION OF TIA1

TIA1 的 TAR 抑制机制

• 批准号: 6087584
• 负责人: IRA J MILLER
• 金额: $ 4.33万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-10-08 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6087584
• 关键词: RNA binding protein; animal tissue; cell line; environmental stressor; fibroblasts; gene expression; gene induction /repression; genetic regulation; genetic regulatory element; genetic transcription; genetic translation; immunoprecipitation; protein binding

The long-term goal of this project is to understand the role of TIA-1 and TIAR in cellular metabolism. Our working hypothesis is that these proteins bind to specific subsets of mRNAs to regulate their translation, perhaps in response to environmental stress. The proposed project will promote this end by examining functional interactions between TIAR and its putative TIA-1 mRNA substrate in intact cells. Analysis of this prototypical interaction will enable us to assess additional potential substrates by nucleotide homology, to further our understanding of these RNA-binding proteins in their proposed role in the stress response.

这个项目的长期目标是了解TIA-1的作用