STRUCTURE OF CYTOCHROME P450 REDOX PARTNER COMPLEXES
细胞色素 P450 氧化还原伙伴复合物的结构
基本信息
- 批准号:6018443
- 负责人:
- 金额:$ 3.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-01 至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Interaction of the P450 enzymes with their redox partners and the
mechanism of electron transfer are the most important and intriguing
problems in the area of P450 research. The crystal structures of four
bacterial P450s, the catalytical domain of microsomal P450 reductase, and
the NMR structure of putidaredoxin are known. However, knowledge of these
structures does not directly answer where and how the proteins interact.
Since interaction of other electron transfer proteins in crystallographic
electron transfer complexes was shown to be specific and relevant to that
occurring in a solution, we propose that crystallization of P450-redox
partner complexes will enable the identification of interaction sites,
conformation changes occurring upon binding, and the electron pathway from
one co-factor to another. The P450cam electron transfer system and the
heme/FMN-binding domain of flavocytochrome P450BM-3, a functional and
structural analog to microsomal P450s and reductase, are the best
candidates for crystallization trials of Class I and Class II
monooxygenase systems, respectively.
Having crystallized both the covalently linked heme/FMN-binding domain and
the non-covalent complex between the separate heme-and FMN-binding domains
of P450BM-3, we are in an excellent position to solve these structures,
which will, undoubtedly, lead to our better understanding of the mechanism
and function of microsomal P450-dependent monooxygenase systems.
P450酶与其氧化还原伙伴的相互作用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Irina F Sevrioukova其他文献
Irina F Sevrioukova的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Irina F Sevrioukova', 18)}}的其他基金
Toxicological importance of CYP3A4 catalysis and inhibition
CYP3A4 催化和抑制的毒理学重要性
- 批准号:
10358992 - 财政年份:2016
- 资助金额:
$ 3.68万 - 项目类别:
Toxicological importance of CYP3A4 catalysis and inhibition
CYP3A4 催化和抑制的毒理学重要性
- 批准号:
10580711 - 财政年份:2016
- 资助金额:
$ 3.68万 - 项目类别:
Toxicological importance of CYP3A4 catalysis and inhibition
CYP3A4 催化和抑制的毒理学重要性
- 批准号:
9275987 - 财政年份:2016
- 资助金额:
$ 3.68万 - 项目类别:
STUDIES ON STRUCTURAL HOMOLOGUES, PUTIDAREDOXIN REDUCTASE & APOPTOSIS INDUCING F
腐胺氧还蛋白还原酶结构同系物的研究
- 批准号:
7370370 - 财政年份:2006
- 资助金额:
$ 3.68万 - 项目类别:
STRUCTURAL HOMOLOGUES, PUTIDAREDOXIN REDUCTASE & APOPTOSIS INDUCING FACTOR
结构同系物,腐胺氧还蛋白还原酶
- 批准号:
6976260 - 财政年份:2004
- 资助金额:
$ 3.68万 - 项目类别:
相似海外基金
CAREER: Unveiling the structure and stability of prenucleation clusters and their roles in crystallization pathway and final crystal structure
职业:揭示成核前团簇的结构和稳定性及其在结晶途径和最终晶体结构中的作用
- 批准号:
2338173 - 财政年份:2024
- 资助金额:
$ 3.68万 - 项目类别:
Continuing Grant
CAREER: Nanoscale Resolution of Near-Interface Crystallization in Multicomponent Semicrystalline Polymeric Materials
职业:多组分半晶聚合物材料中近界面结晶的纳米级分辨率
- 批准号:
2338613 - 财政年份:2024
- 资助金额:
$ 3.68万 - 项目类别:
Continuing Grant
CAREER: Evaluating Theories of Polymer Crystallization by Directly Calculating the Nucleation Barrier in a Polymer Melt
职业:通过直接计算聚合物熔体中的成核势垒来评估聚合物结晶理论
- 批准号:
2338690 - 财政年份:2024
- 资助金额:
$ 3.68万 - 项目类别:
Continuing Grant
Anti-solvent crystallization及び ED-Rプロセスを用いる新規LiB再生システムの構築
采用反溶剂结晶和ED-R工艺构建新型LiB再生系统
- 批准号:
24K08133 - 财政年份:2024
- 资助金额:
$ 3.68万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Creation of the active fiber-type device by glass crystallization for next-generation light control
通过玻璃结晶创建用于下一代光控制的有源光纤型装置
- 批准号:
22KJ0290 - 财政年份:2023
- 资助金额:
$ 3.68万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Understanding Plant Based Fat Crystallization for the Design of Vegan and Low Carbon Footprint Chocolate
了解植物脂肪结晶在纯素和低碳足迹巧克力设计中的应用
- 批准号:
BB/Y512692/1 - 财政年份:2023
- 资助金额:
$ 3.68万 - 项目类别:
Training Grant
General applicability and quantitative predictability of complex population-based crystallization models
基于复杂群体的结晶模型的普遍适用性和定量可预测性
- 批准号:
2903595 - 财政年份:2023
- 资助金额:
$ 3.68万 - 项目类别:
Studentship
Elucidation of the origin of zeolite crystallization and innovation of production methods
沸石结晶起源的阐明及生产方法的创新
- 批准号:
23H05454 - 财政年份:2023
- 资助金额:
$ 3.68万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
Biopharmaceuticals purification by continuous membrane-assisted crystallization achieving lower cost and intensified processes (BIOPURE)
通过连续膜辅助结晶进行生物制药纯化,实现更低的成本和强化工艺 (BIOPURE)
- 批准号:
10082780 - 财政年份:2023
- 资助金额:
$ 3.68万 - 项目类别:
EU-Funded
Development of a Novel Method for Producing Pharmaceutical Multi-Phase Solid Using Melt Crystallization
开发利用熔融结晶生产药物多相固体的新方法
- 批准号:
23KJ0860 - 财政年份:2023
- 资助金额:
$ 3.68万 - 项目类别:
Grant-in-Aid for JSPS Fellows